[The anti-leukemic effects of imatinib, daunorubicin and bortezomib on two leukemia cell lines with Ph(+)].

Author: ChangHong, GongYu-ping, XingHong-yuan, YangLei, YangXi, ZhengBo-hui, ZhouRui-qing

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To study the proliferative inhibition effects of imatinib, daunorubicin and bortezomib on two leukemia cell lines with Ph(+), chronic myelogenous leukemia cell line K562 expressing P210 protein and acute lymphoblastic leukemia cell line SUP-B15 expressing P190 protein. METHODS: (1) The c...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/21302443

データ提供:米国国立医学図書館(NLM)

Imatinib, Daunorubicin, and Bortezomib: Anti-Leukemic Effects on Ph(+) Leukemia Cell Lines

Leukemia, a type of blood cancer, presents a significant challenge to healthcare professionals. Finding effective treatments for leukemia is a major focus of ongoing research.

This study investigates the anti-leukemic effects of imatinib, daunorubicin, and bortezomib on two Ph(+) leukemia cell lines: K562 and SUP-B15. The researchers found that all three drugs showed anti-cancer effects on these cell lines, suggesting their potential for treating Ph(+) leukemia. However, the study also found that K562 cells were more sensitive to imatinib, while SUP-B15 cells were more sensitive to daunorubicin and bortezomib.

Drug Sensitivity in Ph(+) Leukemia

This study highlights the importance of understanding drug sensitivity in Ph(+) leukemia. The findings suggest that different drugs may have varying levels of effectiveness depending on the specific type of leukemia cell. This knowledge can help clinicians choose the most appropriate treatment for each patient, potentially improving treatment outcomes.

Implications for Leukemia Treatment

This study provides insights into the potential of imatinib, daunorubicin, and bortezomib for treating Ph(+) leukemia. It suggests that these drugs could be valuable tools in the fight against this type of cancer. Further research is needed to confirm these findings and explore the optimal use of these drugs in treating Ph(+) leukemia.

Dr.Camel's Conclusion

Leukemia, like a desert sandstorm, can be a formidable opponent, but with the right tools and strategies, we can combat this disease. This study sheds light on the potential of certain drugs to combat Ph(+) leukemia, offering hope for patients and researchers alike. It reminds us that the fight against cancer requires a multifaceted approach, with continuous research and innovation driving towards more effective treatments.
Date :
  1. Date Completed 2011-09-29
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

21302443

DOI: Digital Object Identifier

21302443

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PICO Info
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Languages

Chinese

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