Efficacy and safety of oral lubiprostone in constipated patients with or without irritable bowel syndrome: a randomized, placebo-controlled and dose-finding study.

Author: FukudoS, HongoM, KanekoH, UenoR

Paper Details 
Original Abstract of the Article :
BACKGROUND: Lubiprostone is a prostone analog with a novel mechanism of action involving type-2 chloride channel activation. The aim of this work was to perform a dose-finding study for lubiprostone for the treatment of constipation with or without irritable bowel syndrome (IBS) in Japan. METHODS: ...See full text at original site
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引用元:
https://doi.org/10.1111/j.1365-2982.2011.01668.x

データ提供:米国国立医学図書館(NLM)

Lubiprostone: A New Oasis in the Desert of Constipation

The desert of [constipation] can be a challenging and uncomfortable place to navigate. This study embarks on a journey to explore the efficacy and safety of [lubiprostone] for the treatment of constipation, both with and without [irritable bowel syndrome] (IBS). Researchers conducted a randomized, placebo-controlled, dose-finding study involving patients with chronic idiopathic constipation (CIC), administering various doses of lubiprostone over a two-week period. The study revealed a statistically significant and dose-dependent increase in spontaneous bowel movements, indicating that lubiprostone effectively alleviated constipation symptoms in patients with or without IBS. Notably, lubiprostone was well-tolerated, with no serious side effects reported.

Lubiprostone: A Promising Relief for Constipation

This study suggests that lubiprostone holds promise as an effective and safe treatment option for constipation, offering relief to individuals struggling with this common condition. The dose-dependent response observed in the study highlights the importance of individualized treatment approaches, ensuring optimal therapeutic benefits while minimizing potential side effects. The study's findings pave the way for further research and clinical applications of lubiprostone as a potential oasis in the desert of constipation.

Constipation: A Common Concern

Constipation is a widespread concern affecting individuals of all ages. While it's often considered a minor inconvenience, it can significantly impact quality of life. If you're experiencing chronic constipation, it's essential to consult with your healthcare provider to discuss potential treatment options, including lubiprostone, and address any underlying factors contributing to your condition. Don't let the desert of constipation rule your life; seek help and find relief.

Dr.Camel's Conclusion

This study showcases the potential of lubiprostone as an effective and safe treatment for constipation, offering a beacon of hope in the desert of this common condition. The study's results highlight the importance of personalized treatment approaches and the need for further research to optimize the use of lubiprostone. It's a reminder that even in the face of uncomfortable and challenging conditions, there are options for finding relief and improving quality of life.

Date :
  1. Date Completed 2011-08-29
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

21303430

DOI: Digital Object Identifier

10.1111/j.1365-2982.2011.01668.x

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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