Ticagrelor: from concept to clinical evaluation.

Author: MenownIan B A, ShandJames A, StoreyRobert F

Paper Details 
Original Abstract of the Article :
Dual antiplatelet therapy with aspirin and a platelet adenosine diphosphate P2Y(12) receptor blocker reduces the risk of major adverse cardiovascular events following percutaneous coronary intervention or an acute coronary syndrome. Clopidogrel is the most widely used P2Y(12) receptor blocker, but h...See full text at original site
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引用元:
https://doi.org/10.2217/bmm.11.4

データ提供:米国国立医学図書館(NLM)

Ticagrelor: A Promising New P2Y12 Receptor Blocker

This article examines the development and clinical evaluation of ticagrelor, a novel P2Y12 receptor blocker for the prevention of cardiovascular events. The researchers delve into the pharmacokinetic and pharmacodynamic properties of ticagrelor, highlighting its superior speed of onset, greater maximal inhibition of platelet aggregation, and less variability in response compared to clopidogrel, a commonly used P2Y12 receptor blocker. The article discusses the results of the landmark PLATO trial, which demonstrated that ticagrelor significantly reduced the risk of major adverse cardiovascular events in patients with acute coronary syndrome. The research highlights the potential of ticagrelor as a valuable tool for preventing cardiovascular events and improving patient outcomes.

Ticagrelor: A Step Forward in Cardiovascular Prevention

The study's findings suggest that ticagrelor may be a significant advance in the field of cardiovascular prevention. The drug's superior pharmacodynamic properties, combined with its proven efficacy in the PLATO trial, offer a compelling rationale for its use in patients with acute coronary syndrome. This research underscores the ongoing efforts to develop more effective and targeted therapies for cardiovascular disease.

Navigating the Desert of Cardiovascular Disease: Seeking New Oases

Cardiovascular disease remains a leading cause of death worldwide. This study offers a glimmer of hope in the fight against this silent threat, highlighting the potential of ticagrelor as a valuable tool for preventing cardiovascular events and improving patient outcomes. The research emphasizes the importance of ongoing innovation in the field of cardiovascular medicine, seeking new solutions to address the challenges of this complex and often debilitating disease. It's a journey across the vast desert of cardiovascular disease, seeking oases of effective therapies and improved patient well-being.

Dr. Camel's Conclusion

This article highlights the exciting potential of ticagrelor as a promising new P2Y12 receptor blocker for the prevention of cardiovascular events. The drug's superior pharmacodynamic properties, combined with its proven efficacy in clinical trials, suggest that it may offer a significant advance in the field of cardiovascular prevention. The research inspires continued innovation in the development of new and improved therapies to address the global challenge of cardiovascular disease.

Date :
  1. Date Completed 2011-06-15
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

21319965

DOI: Digital Object Identifier

10.2217/bmm.11.4

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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