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Drug interaction study between bupropion and ticlopidine in male CF-1 mice.

Author: HassanHazem EmadEldin, MoellerBryant Michael, MolnariJillissa Christine, MyersAlan Lewis

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the potential pharmacokinetic interaction between bupropion and ticlopidine in mice. The results suggest a significant interaction, with ticlopidine inhibiting the metabolism of bupropion. This finding highlights the potential for drug interactions when co-administering bupropion with CYP2B6 inhibitors.
Paper Details　
Original Abstract of the Article :
Bupropion is an atypical antidepressant that is biotransformed in humans to its major active metabolite hydroxybupropion by cytochrome P450 2B6 (CYP2B6). Co-administration of bupropion with an inhibitor of CYP2B6 can result in a serious drug interaction, leading to bupropion related adverse effects ...See full text at original site
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引用元：
https://doi.org/10.1248/bpb.34.447

データ提供：米国国立医学図書館（NLM）

Bupropion and Ticlopidine: A Drug Interaction in the Desert

This study investigates a potential drug interaction between bupropion, an antidepressant, and ticlopidine, an antiplatelet agent, in mice. Bupropion is metabolized by an enzyme called CYP2B6, and ticlopidine can inhibit this enzyme, potentially leading to increased levels of bupropion in the body. The researchers found that co-administering bupropion and ticlopidine in mice resulted in significantly higher bupropion levels, suggesting a potential for drug interactions in humans. This research underscores the importance of considering potential drug interactions when prescribing medications.

Drug Interactions: A Desert of Unexpected Encounters

The study's findings highlight the potential for drug interactions between bupropion and ticlopidine, two medications commonly used to treat different conditions. This research serves as a reminder that medications can interact in complex ways, and it's crucial for healthcare professionals to be aware of these potential interactions to ensure patient safety. The desert of drug interactions can be full of unexpected encounters, and careful navigation is essential for optimal health.

Medication Safety: A Journey Through the Desert

This study underscores the importance of discussing medication history with healthcare providers to ensure medication safety. The findings highlight the potential for drug interactions between bupropion and ticlopidine, emphasizing the importance of considering potential interactions when prescribing medications. This research reminds us that the desert of medication can be challenging, but with careful navigation and communication, we can ensure a safe and effective journey.

Dr.Camel's Conclusion

This study investigates a potential drug interaction between bupropion and ticlopidine in mice. The findings suggest a potential for drug interactions between these medications in humans, highlighting the importance of considering potential interactions when prescribing medications.
Date :
  1. Date Completed 2011-11-22
  2. Date Revised 2019-07-20
Further Info :

Pubmed ID

21372402

DOI: Digital Object Identifier

10.1248/bpb.34.447

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Article Analysis
・Side Effects of ticlopidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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