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Enhanced uridine bioavailability following administration of a triacetyluridine-rich nutritional supplement.

Author: CheungPolly, JacobPeyton, MulliganKathleen, RomanMark C, SchambelanMorris, WalkerUlrich A, WeinbergMelissa E, WenMichael

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study investigates the use of uridine as a therapy for hereditary orotic aciduria and other mitochondrial dysfunction disorders, including HIV-related toxicities. A food supplement containing nucleosides, NucleomaxX®, was found to increase plasma uridine levels to supraphysiologic levels, potentially improving uridine's bioavailability.
Paper Details　
Original Abstract of the Article :
Uridine is a therapy for hereditary orotic aciduria and is being investigated in other disorders caused by mitochondrial dysfunction, including toxicities resulting from treatment with nucleoside reverse transcriptase inhibitors in HIV. Historically, the use of uridine as a therapeutic agent has bee...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040752/

データ提供：米国国立医学図書館（NLM）

Enhanced Uridine Bioavailability with Triacetyluridine Supplement

Uridine, a naturally occurring nucleoside, has potential therapeutic applications in various medical conditions, including hereditary orotic aciduria and mitochondrial dysfunction. This study explores the bioavailability of uridine following administration of a triacetyluridine-rich nutritional supplement, investigating a potential method for enhancing its therapeutic efficacy. The authors examine the impact of this supplement on uridine levels in the bloodstream.

Unlocking the Therapeutic Potential of Uridine

The research demonstrates the effectiveness of a triacetyluridine-rich supplement in significantly increasing uridine levels in the bloodstream. This could potentially improve the therapeutic efficacy of uridine in conditions where it is used to treat metabolic disorders. The findings encourage further investigation into the potential of this approach to enhance uridine's therapeutic benefits.

Exploring Novel Delivery Strategies for Therapeutic Agents

The study highlights the importance of developing innovative delivery strategies to enhance the bioavailability and therapeutic efficacy of medications. This is particularly relevant for agents that have limited absorption or are rapidly metabolized in the body. The research offers a promising approach to optimize uridine's therapeutic potential and explores the potential of targeted delivery systems to enhance the effectiveness of other medications.

Dr.Camel's Conclusion

Just as the desert sands hold secrets beneath their surface, so too do the compounds we use as medicine. This research, like a desert explorer uncovering a hidden oasis, reveals a novel way to enhance the bioavailability of uridine. By refining our delivery systems, we can unlock the therapeutic potential of this valuable nucleoside and pave the way for new treatment strategies.
Date :
  1. Date Completed 2011-09-01
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21379380

DOI: Digital Object Identifier

PMC3040752

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Languages

English

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