Intensive statin therapy compared with moderate dosing for prevention of cardiovascular events: a meta-analysis of >40 000 patients.

Author: BerwangerOtavio, BrielMatthias, EyawoOghenowede, MillsEdward J, MillsFergal, O'ReganChristopher, WuPing

Paper Details 
Original Abstract of the Article :
Statin therapy is associated with important benefits for patients at risk of, and with, established cardiovascular disease. There is widespread interest in whether intensive dosing of statins yields larger treatment effects. We aimed to determine if intensive dosing is clinically important using a m...See full text at original site
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引用元:
https://doi.org/10.1093/eurheartj/ehr035

データ提供:米国国立医学図書館(NLM)

Intensive Statin Therapy for Cardiovascular Health

In the vast desert of cardiovascular research, we are constantly seeking new ways to protect our hearts, like a camel searching for the most nourishing oasis. This study dives into the world of statins, powerful medications that help regulate cholesterol levels. The researchers wanted to explore whether taking a higher dose of statins (intensive therapy) would provide more benefits than taking a moderate dose for patients at risk of, or already experiencing, cardiovascular disease. To answer this, they conducted a meta-analysis, which is like combining the results of many different studies like gathering precious jewels from scattered oases. This allowed them to examine a large number of patients, ensuring a comprehensive understanding of the effects of intensive statin therapy.

Intensive Statin Therapy: A Deeper Dive

Their findings revealed that while statins offer significant benefits in cardiovascular health, the results suggested that there wasn't a clinically significant difference between intensive and moderate statin dosing. It's like finding multiple oases, but the amount of water available isn't drastically different between them. This doesn't diminish the value of statins, but it provides valuable information for healthcare professionals to consider when choosing the best treatment plan for their patients.

Balancing the Scales of Cardiovascular Health

This research emphasizes the importance of personalized medicine, considering individual factors like risk profile and health history. For some individuals, a moderate dose may be sufficient to achieve the desired results, while others might benefit from higher doses. As with navigating the desert, finding the right balance is key. This study also underscores the need for continued research to explore the long-term impacts of statins and to develop even more effective strategies for cardiovascular protection.

Dr.Camel's Conclusion

This research underscores the importance of considering the individual needs of patients when prescribing statins, reminding us that even in the vast desert of cardiovascular health, individual oases hold unique characteristics. While intensive statin therapy may not be the magic bullet we've been searching for, the study provides valuable insights for guiding future research and ensuring optimal patient care.

Date :
  1. Date Completed 2012-01-06
  2. Date Revised 2011-06-02
Further Info :

Pubmed ID

21385791

DOI: Digital Object Identifier

10.1093/eurheartj/ehr035

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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