Paper Details

  1. Home
  2. Paper Details

A randomized double-blind clinical trial of a mammalian cell-derived recombinant DNA hepatitis B vaccine compared with a plasma-derived vaccine.

Author: BristowN J, CoatesR A, CoreyP N, HallidayM L, RankinJ G, StricklerA C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A new recombinant DNA hepatitis B vaccine (Betagen) was compared to a licensed plasma-derived vaccine (Heptavax-B). Both vaccines showed similar seroconversion rates, but Heptavax-B had a significantly higher geometric mean titer of antibody.
Paper Details　
Original Abstract of the Article :
Eight hundred volunteers from heath care and emergency fields participated in a randomized double-blind clinical trial of a new experimental mammalian cell-derived recombinant DNA hepatitis B vaccine (Betagen) compared with a licensed plasma-derived vaccine (Heptavax-B). Vaccine injections (20 micro...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/2141247

データ提供：米国国立医学図書館（NLM）

A New Era of Hepatitis B Vaccination: Comparing Mammalian Cell-Derived and Plasma-Derived Vaccines

Hepatitis B is a serious viral infection that can lead to liver damage. This study compares the effectiveness of two types of hepatitis B vaccines: a mammalian cell-derived recombinant DNA vaccine and a plasma-derived vaccine. The goal is to determine the efficacy and safety of the new recombinant DNA vaccine.

The Recombinant DNA Vaccine: A Promising Alternative

The study found that the recombinant DNA vaccine (Betagen) was as effective as the plasma-derived vaccine (Heptavax-B) in inducing an immune response. However, the plasma-derived vaccine generated higher antibody levels. This research highlights the potential of recombinant DNA vaccines as an alternative to traditional plasma-derived vaccines. It's a groundbreaking discovery, like finding a hidden oasis in a vast desert, offering a new solution to a challenging health problem.

Protecting Against Hepatitis B: An Essential Step

Hepatitis B vaccination is a crucial preventative measure against a serious infection. This study provides valuable insights into the effectiveness and safety of a new recombinant DNA vaccine, offering hope for a wider range of vaccination options. It's a reminder that research and innovation are essential for safeguarding our health, just like a camel adapting to the changing landscape of a desert.

Dr.Camel's Conclusion

Hepatitis B is a serious threat, but research continues to provide new and innovative solutions. This study's comparison of recombinant DNA and plasma-derived vaccines offers a glimpse into the future of hepatitis B vaccination. It's a testament to the power of scientific exploration, much like a camel traversing a vast desert, searching for the best path forward.
Date :
  1. Date Completed 1990-07-18
  2. Date Revised 2007-11-15
Further Info :

Pubmed ID

2141247

DOI: Digital Object Identifier

2141247

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.