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Tipranavir/ritonavir induction of buprenorphine glucuronide metabolism in HIV-negative subjects chronically receiving buprenorphine/naloxone.

Author: AndrewsLaurie, BruceR Douglas, ChodkowskiDiane, FangWenfang B, FriedlandGerald H, MoodyDavid E

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Tipranavir is a drug that is used to treat HIV. Buprenorphine is a drug that is used to treat opioid addiction. Previous studies have shown that when these two drugs are given together, they can reduce the levels of buprenorphine's primary metabolite in the body. This study is investigating how tipranavir affects the breakdown of buprenorphine.
Paper Details　
Original Abstract of the Article :
Previous reports on the pharmacokinetic of tipranavir (TPV) and buprenorphine (BUP)/ naloxone found that coadministration resulted in an 80% reduction in the area under the curve AUC of the primary BUP metabolite, norBUP, without any pharmacodynamic consequences. This study was conducted to characte...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.3109/00952990.2011.568081

データ提供：米国国立医学図書館（NLM）

Tipranavir/Ritonavir: A Desert Storm on Buprenorphine Metabolism

The realm of drug interactions can be a complex landscape, like a desert teeming with unexpected shifts in the sands. This study delves into the intricate interaction between tipranavir (TPV) and buprenorphine (BUP), two medications used for different medical conditions. The study reveals that coadministration of TPV/ritonavir with BUP significantly reduces the levels of norBUP, a key metabolite of BUP. This fascinating finding underscores the importance of carefully considering drug interactions and their potential impact on treatment outcomes.

The Shifting Sands of Metabolism

The study's findings reveal that TPV/ritonavir can significantly alter the metabolism of BUP, a process akin to a desert wind reshaping the dunes. This unexpected interaction can lead to reduced levels of norBUP, potentially affecting the efficacy of BUP treatment. This finding underscores the crucial role of pharmacokinetic considerations in drug development and the need for careful monitoring when combining medications.

Navigating the Desert of Drug Interactions

This research highlights the complex interplay of drugs within the body, a process as intricate as the shifting sands of a desert. This understanding is crucial for clinicians to navigate the potential impact of drug interactions, ensuring that patients receive optimal treatment and avoiding unexpected side effects.

Dr.Camel's Conclusion

This study emphasizes the importance of understanding drug interactions, a crucial aspect of safe and effective medication use. The research highlights the significant impact of TPV/ritonavir on BUP metabolism, providing valuable insights for clinicians and patients alike.

Date :
  1. Date Completed 2011-11-21
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21438849

DOI: Digital Object Identifier

10.3109/00952990.2011.568081

Related Literature

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・Effects of tipranavir
SNS
PICO Info
in preparation
Languages

English

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