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Efficacy and safety of topiramate on weight loss: a meta-analysis of randomized controlled trials.

Author: AzevedoM J, CananiL H, GrossJ L, KramerC K, LeitãoC B, PintoL C

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Topiramate is a medication that can help people lose weight. In clinical trials, people taking topiramate lost an average of 5.34 kg more than those taking a placebo. The effectiveness of topiramate for weight loss was found to be related to the duration of treatment and dosage. For example, people taking 96-200 mg of topiramate per day for longer than 28 weeks lost an average of 6.58 kg more than those taking a placebo, while those taking topiramate for 28 weeks or less lost an average of 4.11 kg more than those taking a placebo. Topiramate was associated with side effects, such as paraesthesia, taste impairment, and psychomotor disturbances. Overall, topiramate may be a helpful treatment option for obesity, but potential side effects need to be considered.
Paper Details　
Original Abstract of the Article :
Topiramate was associated with weight loss in clinical trials. We summarize the evidence on the efficacy and safety of topiramate in the treatment of overweight/obesity. The databases Medline, Embase, and Cochrane were searched. Randomized controlled studies with at least 16 weeks of duration that r...See full text at original site
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引用元：
https://doi.org/10.1111/j.1467-789X.2010.00846.x

データ提供：米国国立医学図書館（NLM）

Topiramate: A Promising Adjunct for Weight Loss

Obesity is a major public health concern, and new treatment options are constantly being explored. This meta-analysis examines the effectiveness and safety of topiramate, a medication typically used for epilepsy, in promoting weight loss. The authors pooled data from multiple studies to assess the drug's impact on weight and adverse events.

Topiramate: A Potentially Effective Weight Loss Tool

The meta-analysis revealed that topiramate was associated with significant weight loss compared to placebo. The authors emphasize the importance of considering the potential side effects of topiramate, particularly paraesthesia, taste impairment, and psychomotor disturbances. It's like discovering a new tool for navigating the desert of obesity, a tool that can help you reach your destination but may require careful handling and attention to potential hazards along the way.

Navigating the Desert of Weight Loss: Considerations and Cautions

This research highlights the potential of topiramate as a valuable adjunct in weight loss management, but it also emphasizes the importance of carefully considering the risks and benefits. It's like planning a journey through a vast and challenging desert, where the right tools and knowledge are crucial for a successful expedition. It's essential to weigh the potential benefits of topiramate against the potential side effects and to consult with a healthcare professional for personalized guidance.

Dr.Camel's Conclusion

This meta-analysis offers valuable insights into the potential of topiramate as a weight loss aid, but it also underscores the importance of caution and personalized treatment approaches. It's a reminder that the journey of weight loss is a complex one, requiring a comprehensive understanding of both the potential benefits and risks of different treatment options. It's a journey that requires careful planning, vigilance, and a willingness to adapt along the way.

Date :
  1. Date Completed 2011-05-12
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

21438989

DOI: Digital Object Identifier

10.1111/j.1467-789X.2010.00846.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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