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Pharmacokinetics of oxymorphone in titi monkeys (Callicebus spp.) and rhesus macaques (Macaca mulatta).
Author: ChristeKari L, GraysonJ Kevin, KellyKristi R, LercheNicholas W, PypendopBruno H, StanleyScott D, SummersLaura M
Original Abstract of the Article :
Oxymorphone is a pure μ-opioid receptor agonist that is commonly used in nonhuman primate medicine and surgery to minimize pain ranging in intensity from moderate to severe. We compared pharmacokinetic profiles and physiologic and behavioral responses to oxymorphone between titi monkeys (Callicebus ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061422/
データ提供:米国国立医学図書館(NLM)
Oxymorphone: Pain Relief for Primates
The world of primate medicine is vast and complex, much like a desert with its diverse inhabitants. This research delves into the intricate world of pain management for our primate friends, specifically focusing on the effectiveness of oxymorphone. The study investigated the pharmacokinetic profiles and physiological responses of titi monkeys and rhesus macaques to oxymorphone, a potent pain reliever commonly used in primate healthcare. The researchers used a meticulous approach, administering oxymorphone intravenously to both species and carefully monitoring their responses. This meticulous approach, much like navigating a treacherous desert path, allowed them to identify key differences in how these primates metabolize oxymorphone.
Oxymorphone: A Tailored Approach to Pain
The findings revealed intriguing insights into the distinct pain management needs of these two primate species. Macaques metabolized oxymorphone quicker than titi monkeys, suggesting a need for more frequent administrations in the former. These results highlight the importance of understanding species-specific differences in pain management, as a one-size-fits-all approach may not be effective in the diverse primate world.
Oxymorphone: Balancing Benefits and Risks
While oxymorphone demonstrated remarkable potential for managing pain in both species, it also elicited some side effects. Macaques exhibited signs of itching, while titi monkeys displayed sedation. This highlights the delicate balance between pain relief and potential side effects. Just as a traveler in the desert must carefully consider the risks and benefits of each oasis, healthcare providers must weigh the advantages of oxymorphone against its potential downsides.
Dr.Camel's Conclusion
This study provides valuable insights into the pharmacokinetic properties of oxymorphone in titi monkeys and rhesus macaques. The findings underscore the importance of considering species-specific differences in pain management protocols. As a seasoned researcher, I find this study's meticulous approach to be a testament to the dedication of those who work to ensure the well-being of our primate companions. The study's findings also remind us that, like the sands of the desert, the world of primate medicine is constantly shifting. As we continue to explore this complex landscape, we must remain vigilant in seeking the best possible pain management solutions for our primate friends.
Date :
- Date Completed 2011-08-03
- Date Revised 2021-10-20
Further Info :
Related Literature
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