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Modulation of behavioral phenotypes by a muscarinic M1 antagonist in a mouse model of fragile X syndrome.

Author: BuiNghiem, CarpenterRandall L, PaylorRichard, PerkinsJennie R, VeeraragavanSurabi, Yuva-PaylorLisa A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study provides evidence for overactive M1 receptor signaling in the fragile X knockout (Fmr1 KO) mouse model, suggesting involvement of the M1 receptors in fragile X syndrome. Overactive signaling through the M1 receptor is hypothesized to contribute to the phenotypes seen in fragile X mice.
Paper Details　
Original Abstract of the Article :
Muscarinic acetylcholine receptors (mAChR) are G protein-coupled receptors, widely expressed in the CNS. Electrophysiological and molecular studies have provided evidence for overactive M1 receptor signaling in the fragile X knockout (Fmr1 KO) mouse model, suggesting the involvement of the M1 recept...See full text at original site
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引用元：
https://doi.org/10.1007/s00213-011-2276-6

データ提供：米国国立医学図書館（NLM）

Muscarinic M1 Antagonists: A Potential Treatment for Fragile X Syndrome

This research examines the role of muscarinic acetylcholine receptors (mAChR), particularly the M1 subtype, in fragile X syndrome, a genetic disorder that affects brain development. Imagine it as exploring a desert oasis where the delicate balance of the ecosystem is disrupted – the researchers are investigating how a specific receptor in the brain might be involved in fragile X syndrome.

Targeting the M1 Receptor

The researchers found that M1 receptor signaling is overactive in a mouse model of fragile X syndrome, suggesting that targeting this receptor could be a potential therapeutic strategy. It's like finding a key to unlocking a hidden water source – the researchers are exploring a new avenue for treating this challenging condition.

New Hope for Fragile X Syndrome

This research offers a promising avenue for treating fragile X syndrome. By targeting the M1 receptor, the researchers hope to develop new therapies that could alleviate some of the symptoms and improve the quality of life for individuals with this disorder. It's like discovering a new path through the desert – a route that could lead to a brighter future for those affected by fragile X syndrome.

Dr. Camel's Conclusion

This research sheds light on the potential of targeting the M1 receptor as a novel treatment strategy for fragile X syndrome. It's a testament to the ongoing efforts in finding new solutions for genetic disorders, offering a glimmer of hope for those seeking improved treatments and care.

Date :
  1. Date Completed 2011-12-27
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21487657

DOI: Digital Object Identifier

10.1007/s00213-011-2276-6

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Languages

English

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