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Effects of localized hydrophilic mannitol and hydrophobic nelfinavir administration targeted to olfactory epithelium on brain distribution.

Author: HoRodney J Y, HoekmanJohn Douglas

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study developed a pressurized olfactory delivery (POD) device to deposit drugs into the olfactory region of the nasal cavity in rats. POD administration of mannitol and nelfinavir provided a significant increase in cortex-to-blood ratio compared to nose drops, suggesting increased direct nose-to-brain transport.
Paper Details　
Original Abstract of the Article :
Many nasally applied compounds gain access to the brain and the central nervous system (CNS) with varying degree. Direct nose-to-brain access is believed to be achieved through nervous connections which travel from the CNS across the cribriform plate into the olfactory region of the nasal cavity. Ho...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134660/

データ提供：米国国立医学図書館（NLM）

Targeting the Olfactory Epithelium for Brain Drug Delivery

In the quest to deliver drugs directly to the brain, scientists have long sought to exploit the olfactory pathway, which connects the nasal cavity to the central nervous system. The authors investigated a novel pressurized olfactory delivery (POD) device that targets the olfactory epithelium, the specialized tissue in the nose responsible for smell. This research explores the potential of this innovative technology for improving drug delivery to the brain.

POD: A Potential Game-Changer for Brain Drug Delivery

The study compared the brain and blood levels of mannitol and nelfinavir, two drugs with differing properties, after nasal administration using either the POD device or traditional nose drops. The results showed a significant advantage for the POD device, demonstrating that targeting the olfactory region led to increased drug levels in the brain. This breakthrough has the potential to revolutionize the way we deliver drugs to the brain, opening new doors for treating neurological disorders.

Navigating the Brain's Intricate Landscape

Imagine a vast desert with hidden oases, each representing a different brain region. Getting drugs to the right oasis can be challenging, but the POD device acts like a skilled navigator, leading the drug directly to the desired target. This research offers a promising approach for delivering drugs to the brain, potentially improving treatment outcomes for a wide range of neurological disorders.

Dr.Camel's Conclusion

The brain is a complex and intricate organ, with its own unique defenses against foreign substances. The POD device offers a novel and potentially more effective way to bypass these defenses, delivering drugs directly to their target destinations in the brain. This research has the potential to significantly improve the treatment of neurological disorders, offering new hope for patients facing these challenges.

Date :
  1. Date Completed 2012-05-16
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

21519984

DOI: Digital Object Identifier

PMC3134660

Related Literature

Article Analysis
・Effects of nelfinavir
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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