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Histologic and cytologic detection of endocrine and reproductive tract effects of exemestane in female rats treated for up to twenty-eight days.

Author: CapponGregg D, ChapinRobert E, HouleChristopher, MirskyMichael L, PotterDavid M, SivaramanLakshmi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study determined the shortest period of time necessary to detect histologic evidence of estrous cycle disruption in Sprague-Dawley rats treated with the aromatase inhibitor exemestane. The study found that vaginal mucification, uterine and cervical epithelial atrophy, and ovarian changes were noted by day 5 and persisted throughout the study. Estrous cycle disruption was confirmed by vaginal smears between days 5 and 8.
Paper Details　
Original Abstract of the Article :
The objective of this study was to determine the shortest period of time necessary to detect histologic evidence of estrous cycle disruption in Sprague-Dawley rats treated for up to 28 days with the aromatase inhibitor exemestane at 1,000 mg/kg. Rats were evaluated on day 5, 8, 15, or 29. Vaginal mu...See full text at original site
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引用元：
https://doi.org/10.1177/0192623311402220

データ提供：米国国立医学図書館（NLM）

Exemestane: A Powerful Aromatase Inhibitor with Potential Endocrine Effects

[Aromatase inhibitors] are commonly used in the treatment of [breast cancer], but their effects on the [endocrine and reproductive systems] are not fully understood. This study investigated the histologic and cytologic effects of [exemestane], an aromatase inhibitor, on the reproductive organs of female rats treated for up to 28 days.

Exemestane: A Powerful Aromatase Inhibitor with Potential Endocrine Effects

The study demonstrates that [exemestane] causes significant changes in the [endocrine and reproductive systems] of female rats, including estrous cycle disruption, uterine and cervical atrophy, and ovarian follicle abnormalities. The researchers observed these effects as early as 5 days after treatment initiation, highlighting the potential for rapid endocrine disruption with exemestane. These findings provide valuable insights into the potential side effects of aromatase inhibitors and emphasize the importance of monitoring for endocrine changes in patients receiving these medications.

Navigating the Complexities of Hormone Therapy: Understanding Potential Side Effects

Hormone therapy, while offering benefits for certain conditions, can also have significant side effects. This study highlights the importance of understanding the potential impact of aromatase inhibitors on the endocrine and reproductive systems. Healthcare providers should be aware of these potential side effects and monitor patients closely for any signs of endocrine disruption. This research contributes to a broader understanding of the complexities of hormone therapy and the importance of personalized approaches to treatment.

Dr. Camel's Conclusion

As a researcher who has been exploring the intricate workings of the endocrine system for years, I find this study to be a valuable contribution to our understanding of the potential side effects of aromatase inhibitors. The study's findings, like a ripple in a still desert pond, remind us of the interconnectedness of the endocrine system and the need for careful consideration of potential consequences when prescribing hormone therapy.
Date :
  1. Date Completed 2011-10-14
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

21540174

DOI: Digital Object Identifier

10.1177/0192623311402220

Related Literature

Article Analysis
・Effects of exemestane
SNS
PICO Info
in preparation
Languages

English

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