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Norepinephrine transporter -3081(A/T) and alpha-2A-adrenergic receptor MspI polymorphisms are associated with cardiovascular side effects of OROS-methylphenidate treatment.

Author: BellgroveMark A, ChoSoo-Churl, CumminsTarrant D R, KimBung-Nyun, KimJae-Won

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Certain norepinephrine gene polymorphisms may be associated with cardiovascular side effects of OROS-MPH in children with ADHD, particularly increases in heart rate and diastolic blood pressure.
Paper Details　
Original Abstract of the Article :
The purpose of this study was to investigate a possible association between norepinephrine genes and cardiovascular side effects of the Osmotic Controlled-Release Oral Delivery System-methylphenidate (OROS-MPH) in Korean children with attention-deficit/hyperactivity disorder (ADHD). One hundred and ...See full text at original site
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引用元：
https://doi.org/10.1177/0269881111405356

データ提供：米国国立医学図書館（NLM）

Norepinephrine Transporter and Cardiovascular Side Effects of Methylphenidate

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder often treated with medications like methylphenidate. This research investigates the potential association between genetic variations in norepinephrine-related genes and the cardiovascular side effects of methylphenidate treatment. The study focused on the norepinephrine transporter (SLC6A2) and alpha-2A-adrenergic receptor (ADRA2A) genes, examining the potential link between specific genetic variations and changes in heart rate and blood pressure in children with ADHD receiving methylphenidate treatment.

Genetic Variations and Cardiovascular Response

The researchers found a significant association between specific genetic variations in the SLC6A2 and ADRA2A genes and changes in heart rate and blood pressure after methylphenidate treatment. These findings highlight the importance of considering genetic factors when prescribing methylphenidate to children with ADHD, especially for those with specific genetic variations that may predispose them to increased cardiovascular side effects.

Navigating the Desert of Genetic Variability

This research is a reminder that the desert of human genetics is vast and complex, with individual variations influencing responses to medications. It emphasizes the importance of personalized medicine, tailoring treatment approaches to individual genetic profiles to optimize outcomes and minimize potential side effects. It's like navigating a vast desert, where the terrain changes constantly, requiring careful observation and adaptation to ensure a safe and successful journey.

Dr.Camel's Conclusion

This research is a testament to the power of personalized medicine, recognizing the unique genetic variations that can influence individual responses to treatment. The study emphasizes the importance of considering genetic factors when prescribing medications, particularly those with known cardiovascular side effects. It encourages further research into the genetic basis of drug response, paving the way for more precise and personalized approaches to healthcare.

Date :
  1. Date Completed 2012-08-03
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

21628343

DOI: Digital Object Identifier

10.1177/0269881111405356

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Article Analysis
・Side Effects of methylphenidate
SNS
PICO Info
in preparation
Languages

English

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