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Synthesis of 14-alkoxymorphinan derivatives and their pharmacological actions.

Author: SchmidhammerHelmut, SpeteaMariana

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

14-alkoxymorphinans are a promising new class of opioid analgesics with the potential to be safer, more efficacious, and less addictive than current opioids.
Paper Details　
Original Abstract of the Article :
Among opioids, morphinans play an important role as therapeutically valuable drugs. They include pain relieving agents such as naturally occurring alkaloids (e.g. morphine, codeine), semisynthetic derivatives (e.g. oxycodone, oxymorphone, buprenorphine), and synthetic analogs (e.g. levorphanol). Cur...See full text at original site
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引用元：
https://doi.org/10.1007/128_2010_77

データ提供：米国国立医学図書館（NLM）

Morphinans: A Journey Through Opioid Pharmacology

The world of opioids is a complex desert, filled with both powerful pain relief and challenging side effects. Morphinans, a class of opioid drugs, are like camels traversing this desert, carrying the potential for both healing and harm. This study focuses on 14-alkoxymorphinans, a group of morphinan derivatives with modified structures, exploring their potential as safer and more effective analgesics.

Seeking a More Balanced Path in Opioid Therapy

This research explores the exciting potential of 14-alkoxymorphinans as therapeutic agents. By understanding the structure-activity relationships of these morphinan derivatives, researchers hope to develop safer and more effective opioids, minimizing side effects while maximizing pain relief.

Finding a Safer Oasis in the Opioid Desert

This research offers a glimmer of hope in the challenging landscape of opioid therapy. By modifying the structure of morphinans, scientists are seeking to create safer and more effective pain relievers, potentially reducing the risks and improving the lives of patients.

Dr.Camel's Conclusion

The quest for safer and more effective opioid analgesics continues, and this research provides a promising direction. By understanding the intricacies of morphinan structure and function, we can navigate the desert of opioid pharmacology, seeking oases of relief for those in pain.

Date :
  1. Date Completed 2011-06-09
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

21630508

DOI: Digital Object Identifier

10.1007/128_2010_77

SNS
PICO Info
in preparation
Languages

English

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