Efficacy of modafinil on excessive daytime sleepiness in Prader-Willi syndrome.

Author: De CockV Cochen, DieneG, KiefferI, MassonV Dauriac-Le, MimounE, MolinasC, TauberM, TibergeM

Paper Details 
Original Abstract of the Article :
Excessive daytime sleepiness is a frequent and a highly disruptive symptom to the daily routine of children with Prader-Willi Syndrome (PWS) and their families. The objective of the study was to evaluate the efficacy of modafinil, a central stimulant, on excessive daytime sleepiness in children and ...See full text at original site
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引用元:
https://doi.org/10.1002/ajmg.a.34047

データ提供:米国国立医学図書館(NLM)

Investigating Modafinil's Efficacy in Treating Excessive Daytime Sleepiness in Prader-Willi Syndrome

Excessive daytime sleepiness is a common and disruptive symptom for children with Prader-Willi Syndrome (PWS). This research investigated the efficacy of modafinil, a central stimulant, in alleviating this symptom in children and adolescents with PWS. The study employed an open-label pilot design, assessing the impact of modafinil on the Epworth Sleepiness Scale before and after treatment. The findings demonstrated a significant improvement in sleepiness in all patients who received modafinil. This encouraging result suggests that modafinil could be a valuable tool for improving the quality of life for individuals with PWS.

Modafinil Offers Potential Relief for Sleepiness in Prader-Willi Syndrome

The study's results indicate that modafinil has the potential to significantly reduce excessive daytime sleepiness in children with PWS, with all patients showing notable improvement in their Epworth Sleepiness Scale scores. The research also highlights the importance of personalized treatment approaches, considering the individual needs and characteristics of each patient. The study's findings provide a foundation for future research to further investigate the long-term benefits and safety of modafinil in the context of PWS.

Hope on the Horizon: A New Dawn for Children with Prader-Willi Syndrome

Just as a desert bloom can thrive in the harshest conditions, so too can children with Prader-Willi Syndrome find hope and relief from their symptoms. The study's findings offer a glimmer of optimism, suggesting that modafinil could help improve their quality of life and open new avenues for their well-being. The research serves as a reminder that even in the most challenging of circumstances, there is always the potential for positive change and a brighter future.

Dr. Camel's Conclusion

This study sheds light on the potential of modafinil to alleviate a debilitating symptom in children with Prader-Willi Syndrome. The positive results offer a ray of hope for families seeking a better life for their loved ones. Just as a camel can endure the scorching sun of the desert, children with PWS can find strength and resilience in knowing that solutions exist to help them navigate the challenges they face.

Date :
  1. Date Completed 2011-10-14
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

21671379

DOI: Digital Object Identifier

10.1002/ajmg.a.34047

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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