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The importance of high-quality evidence of the long-term impact of nonfatal events used in randomized controlled trials: a case study of prasugrel.

Author: KarnonJ, LuC Y, SorichM J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This article discusses the importance and challenges of using evidence from randomized controlled trials (RCTs) for clinical and policy decisions. It focuses on the case study of prasugrel and its effects on nonfatal myocardial infarction (MI) and nonfatal bleeding.
Paper Details　
Original Abstract of the Article :
Randomized controlled trials (RCTs) are the centerpiece of evidence-based medicine. However, because of the limited follow-up, additional evidence on the long-term consequences of the outcomes used in trials is commonly required for clinical and policy decision making. This article provides insights...See full text at original site
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引用元：
https://doi.org/10.1038/clpt.2011.61

データ提供：米国国立医学図書館（NLM）

The Long-Term Impact of Nonfatal Events in Clinical Trials: A Case Study of Prasugrel

This research explores the importance of considering the long-term consequences of nonfatal events in clinical trials, using prasugrel, a drug used to prevent blood clots, as a case study. The researchers highlight the limitations of relying solely on short-term data from randomized controlled trials (RCTs) to make informed clinical and policy decisions. The study emphasizes the need for additional evidence on the long-term impact of nonfatal events, such as myocardial infarction or bleeding, to provide a more complete picture of the drug's effects.

Beyond Short-Term Outcomes: Unveiling the Long-Term Impact

This research underscores the limitations of focusing solely on short-term outcomes in clinical trials. The authors argue that long-term data on the consequences of nonfatal events, such as myocardial infarction or bleeding, are critical to inform clinical and policy decisions about drug efficacy and safety. This research serves as a reminder that the long-term picture may differ significantly from the short-term view presented in traditional clinical trials.

Long-Term Considerations: Making Informed Decisions

This research emphasizes the importance of considering the long-term impact of medical interventions when making clinical and policy decisions. It is crucial to gather evidence beyond the short-term outcomes reported in traditional clinical trials to provide a more complete understanding of the potential benefits and risks of a treatment.

Dr.Camel's Conclusion

This research is a valuable reminder that the desert of scientific knowledge is vast and multifaceted. The study underscores the importance of looking beyond the immediate horizon of short-term data and considering the long-term consequences of medical interventions. It's like peering through a telescope to see not only the immediate stars but also the galaxies beyond.
Date :
  1. Date Completed 2011-08-23
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

21691272

DOI: Digital Object Identifier

10.1038/clpt.2011.61

Related Literature

Article Analysis
・Side Effects of prasugrel
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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