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Novel silicon-containing analogues of the retinoid agonist bexarotene: syntheses and biological effects on human pluripotent stem cells.
Author: BauerJennifer B, BurschkaChristian, ChristieVictoria B, DörrichSteffen, HendersonAndrew P, LippertW Peter, MarderTodd B, MurrayBridgid A, PrzyborskiStefan A, TackeReinhold, TamsDaniel M, TebbeDavid
Original Abstract of the Article :
Twofold sila-substitution (C/Si exchange) of the clinically used RXR-selective retinoid agonist bexarotene leads to disila-bexarotene, which displays pharmacological potency similar to that of the parent carbon compound, as shown in a HeLa-cell-based RXR assay. Formal exchange of the SiCH₂CH₂ Si gro...See full text at original site
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引用元：
https://doi.org/10.1002/cmdc.201100156
データ提供：米国国立医学図書館（NLM）
Silicon-Containing Analogues of Bexarotene
The field of drug development is constantly searching for new and improved ways to treat various conditions. This research explores the potential of silicon-containing analogues of bexarotene, a retinoid agonist, as potential therapeutic agents for various conditions.
The authors synthesized silicon-containing analogues of bexarotene and investigated their biological effects on human pluripotent stem cells. They were interested in exploring whether these analogues might have different or enhanced biological activity compared to the parent compound.
The study found that the silicon-containing analogues did not exhibit the same differentiation-inducing properties as bexarotene. However, preliminary evidence suggested that these analogues might possess enhanced functions, such as inducing and regulating cell death and cell numbers. While further investigation is needed, this research opens up new possibilities for exploring the therapeutic potential of silicon-containing compounds in various medical fields.
Silicon-Containing Analogues: A New Frontier
This study suggests that silicon-containing analogues of bexarotene might have different biological activity compared to the parent compound. While further research is required to fully understand their potential, this study highlights the value of exploring novel chemical modifications to existing drugs to discover new therapeutic possibilities.
The Future of Drug Development
This research underscores the continuous innovation in drug development, seeking to improve existing treatments and uncover new therapeutic possibilities. The exploration of silicon-containing analogues of bexarotene offers a glimpse into the future of pharmaceutical research, where new compounds and approaches are constantly being investigated to improve patient outcomes.
Dr.Camel's Conclusion
The desert is a realm of endless possibilities, where new life can emerge from seemingly barren landscapes. This research explores the potential of silicon-containing compounds, much like hidden desert oases, to provide new pathways to therapeutic solutions. The journey of drug discovery is an ongoing expedition, and exploring new frontiers, like the incorporation of silicon, can lead to unexpected and potentially life-changing discoveries.
Date :
- Date Completed 2011-11-28
- Date Revised 2018-12-01
Further Info :
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