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Original Abstract of the Article :
In the absence of a better alternative, subcutaneous interferon beta is the standard first-line treatment for relapsing-remitting multiple sclerosis. Fingolimod, an oral immunosuppressant that reduces the circulating lymphocyte count, is in the process of receiving marketing authorisation for this u...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://pubmed.ncbi.nlm.nih.gov/21751747
データ提供:米国国立医学図書館(NLM)
Fingolimod: A New Player in Multiple Sclerosis Treatment
This study explores the use of fingolimod, an oral immunosuppressant, for the treatment of relapsing-remitting multiple sclerosis (RRMS). Think of it as a new oasis in the vast desert of MS treatment options. Fingolimod works by reducing the number of circulating lymphocytes, which are immune cells that can attack the nervous system in MS. The researchers evaluated fingolimod in two clinical trials, comparing it to standard first-line treatment, interferon beta, and a placebo. The results showed that fingolimod modestly prolonged the interval between exacerbations compared to interferon beta, but it did not demonstrate a significant impact on disability progression. While fingolimod shows some promise, the researchers emphasize that further research is needed to understand its long-term safety and efficacy.
A New Oasis with Potential Downsides
The study found that fingolimod was slightly more effective than interferon beta in delaying relapses. However, this improvement was modest and did not translate into a significant impact on disability progression. It's like finding a new oasis in the desert, but with a few unexpected thorns. The researchers also noted potential long-term risks, such as lymphoma and heart failure. These concerns highlight the need for cautious optimism regarding the use of fingolimod.
Navigating the Desert of Multiple Sclerosis Treatment
The study's findings suggest that fingolimod may offer a potential benefit for patients with RRMS, but it's important to be aware of the potential risks and the fact that its long-term effects are still under investigation. When it comes to MS treatment, navigating the desert requires careful consideration of all options. The researchers advocate for continued use of interferon beta as the initial treatment, reserving fingolimod for clinical trials where patients can be closely monitored.
Dr.Camel's Conclusion
Fingolimod offers a promising new approach to treating RRMS, but it's important to remember that its long-term effects are still being studied. The research emphasizes the importance of continued research and careful monitoring of patients using this medication. The desert of MS treatment is vast, and finding the right oasis requires careful consideration and ongoing research.
Date :
- Date Completed 2011-08-04
- Date Revised 2015-11-19
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