Cost and cost-effectiveness of switching from d4T or AZT to a TDF-based first-line regimen in a resource-limited setting in rural Lesotho.

Author: BygraveHelen, ClearySusan, FordNathan, GadotLaurent, GoemaereEric, HilderbrandKatherine, JouquetGuillaume, KranzerKatharina, LeeJanice, MakakoleLipontso, TrivinoLaura, VlahakisNatalie

Paper Details 
Original Abstract of the Article :
BACKGROUND: Latest World Health Organization guidelines recommend shifting away from Stavudine (d4T)-based regimens due to severe side effects. However, widespread replacement of d4T by Tenofovir (TDF) or Zidovudine (AZT) is hampered by cost concerns. METHODS: We established the cost-effectiveness ...See full text at original site
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引用元:
https://doi.org/10.1097/QAI.0b013e31822a9f8d

データ提供:米国国立医学図書館(NLM)

Cost-Effectiveness of Switching to TDF-Based Antiretroviral Regimens in Lesotho

The fight against HIV/AIDS is a global priority, and the development of effective antiretroviral therapies has been a cornerstone of this battle. This research examines the cost-effectiveness of switching from Stavudine (d4T)-based regimens to Tenofovir (TDF)-based regimens in a resource-limited setting in rural Lesotho. The authors employed a comprehensive analysis of cost, utilization, and patient outcomes to determine the optimal approach to first-line antiretroviral therapy.

Prioritizing Cost-Effectiveness in HIV Treatment

The study demonstrates that while TDF-based regimens are more costly than d4T, they are also more effective, leading to fewer side effects and improved quality of life for patients. The findings underscore the importance of considering both cost and effectiveness when making treatment decisions, particularly in resource-limited settings.

Improving HIV Treatment Outcomes

This research highlights the need for greater access to TDF-based antiretroviral therapy in resource-limited settings. By advocating for price reductions and increased generic manufacturing of TDF and its partner drugs, we can improve treatment outcomes for individuals living with HIV/AIDS and make a significant contribution to the global fight against this devastating disease.

Dr. Camel's Conclusion

This study underscores the importance of finding cost-effective solutions for HIV treatment, especially in resource-limited settings. It's a reminder that we must work together to ensure that everyone, regardless of their location, has access to quality healthcare and the best possible treatment options. By prioritizing cost-effectiveness and promoting access to essential medications, we can make a real difference in the lives of individuals living with HIV/AIDS.

Date :
  1. Date Completed 2011-12-07
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

21765366

DOI: Digital Object Identifier

10.1097/QAI.0b013e31822a9f8d

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English

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