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A randomized clinical trial of chlorambucil versus COP in stage B chronic lymphocytic leukemia. The French Cooperative Group on Chronic Lymphocytic Leukemia.

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Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study compared the effectiveness of chlorambucil and a more intensive chemotherapy regimen (COP) in 291 patients with intermediate-stage chronic lymphocytic leukemia (CLL). After a mean follow-up of 53 months, there was no significant difference in overall survival between the two groups. The study found similar survival rates, remission rates, time to disease progression, and causes of death between the groups. This suggests that a more intensive chemotherapy regimen does not improve outcomes for intermediate-stage CLL compared to chlorambucil treatment.
Paper Details　
Original Abstract of the Article :
In 1980, the French Cooperative Group on Chronic Lymphocytic Leukemia started a randomized clinical trial in which intermediate prognosis patients (stage B) received either an indefinite course of chlorambucil (0.1 mg/kg/d) or 12 cycles of the COP regimen (vincristine, cyclophosphamide, and predniso...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2180493

データ提供：米国国立医学図書館（NLM）

Chlorambucil vs. COP: A Journey Through the Desert of Chronic Lymphocytic Leukemia

The desert of chronic lymphocytic leukemia (CLL) is a challenging landscape, with researchers constantly seeking effective treatment strategies. This study compares the effectiveness of two treatment regimens: chlorambucil and COP (vincristine, cyclophosphamide, and prednisone) in patients with stage B CLL. The researchers conducted a long-term clinical trial, comparing the survival rates and treatment outcomes of these two approaches.

A Similar Path Through the Desert

The study found no significant difference in overall survival between the two treatment groups, even after adjusting for prognostic factors. This suggests that both chlorambucil and COP may be equally effective in managing stage B CLL.

Navigating the Desert of CLL: Finding the Right Path

This study highlights the importance of considering individual factors when choosing a treatment regimen for CLL. While both chlorambucil and COP demonstrated similar effectiveness, the best choice may vary based on individual patient characteristics.

Dr.Camel's Conclusion

This study offers valuable insights into the treatment landscape of stage B CLL. While both chlorambucil and COP demonstrate similar effectiveness, individual patient factors should be considered when choosing a treatment regimen. This research is a reminder that navigating the desert of CLL requires a personalized approach.

Date :
  1. Date Completed 1990-05-04
  2. Date Revised 2021-02-16
Further Info :

Pubmed ID

2180493

DOI: Digital Object Identifier

S0006-4971(20)83161-9

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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