Paper Details

  1. Home
  2. Paper Details

Effects of milnacipran, duloxetine and indomethacin, in polyarthritic rats using the Randall-Selitto model.

Author: BardinLaurent, BerrocosoEsther, DepoortèreRonan, LadurePhilippe, MicoJuan Antonio, Newman-TancrediAdrian, VittonOlivier

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Milnacipran, a serotonin and noradrenalin reuptake inhibitor, was effective in reducing pain in a rat model of arthritis.
Paper Details　
Original Abstract of the Article :
Milnacipran, a serotonin and noradrenalin reuptake inhibitor (SNRI), is efficacious in rodents in various models of acute or chronic pain (traumatic, neuropathic, inflammatory, visceral). However, its activity against arthritic pain has never been explored. Here, we assessed the activity of acute tr...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/21841543

データ提供：米国国立医学図書館（NLM）

Milnacipran: A Potential Treatment for Arthritic Pain

This research investigates the efficacy of milnacipran, a serotonin and noradrenalin reuptake inhibitor (SNRI), in treating arthritic pain in a polyarthritic rat model. The authors evaluated the analgesic effects of milnacipran in comparison to duloxetine, another SNRI, and indomethacin, a nonsteroidal anti-inflammatory drug. Their findings demonstrate that milnacipran was significantly effective in reducing arthritic pain at both low and high pressure levels, suggesting its potential as a therapeutic agent for treating pain associated with chronic inflammatory conditions, such as arthritis.

Milnacipran: A Promising Candidate for Arthritic Pain Relief

This research provides evidence for the potential of milnacipran in treating arthritic pain. The study's findings suggest that milnacipran may offer a new treatment option for patients suffering from chronic inflammatory pain, such as arthritis.

Managing Arthritic Pain: Exploring Different Treatment Options

Arthritis can cause significant pain and disability. This research highlights a potential new treatment option for arthritic pain, offering hope for patients seeking relief.

Dr.Camel's Conclusion

This study, like a camel caravan finding a new oasis in the desert, offers hope for patients with arthritic pain. Milnacipran, with its promising analgesic effects, holds the potential to provide relief from this debilitating condition.

Date :
  1. Date Completed 2011-12-13
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

21841543

DOI: Digital Object Identifier

00008877-201109000-00027

Related Literature

Article Analysis
・Effects of milnacipran
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.