Paper Details
- Home
- Paper Details
Immunosuppressive effects and mechanisms of leflunomide in dengue virus infection of human dendritic cells.
Author: ChangDeh-Ming, ChenPei-Chih, HoLing-Jun, HsuSeng-Ting, LaiJenn-Haung, TsaiYi-Ting, WuWan-Lin
Original Abstract of the Article :
BACKGROUND: Dengue virus (DENV) infection is a serious public health issue without specific treatment. We examined the potential immunomodulatory effects of leflunomide, a dihydroorotate dehydrogenase inhibitor commonly prescribed for arthritis, in DENV-stimulated monocyte-derived dendritic cells (m...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1007/s10875-011-9578-7
データ提供:米国国立医学図書館(NLM)
Leflunomide: A Potential Ally Against Dengue Virus
The world of [immunology] is continuously searching for effective treatments for [dengue virus infection], a mosquito-borne disease that poses a significant health threat worldwide. This study explores the potential of [leflunomide], a drug commonly used for [arthritis], in modulating the immune response to [dengue virus] infection.
Leflunomide: A Suppressor of Dengue Virus Immune Response
The study found that [leflunomide] effectively inhibited the production of [cytokines and chemokines] from [dendritic cells] infected with [dengue virus]. This effect was linked to the suppression of key signaling pathways, suggesting that [leflunomide] might be able to dampen the excessive immune response that can contribute to the severity of [dengue virus infection]. This is like calming a desert storm – [leflunomide] acts as a soothing agent, mitigating the harmful effects of the immune system's response to the virus.
A Potential New Weapon in the Fight Against Dengue
The study's findings offer promising insights into the potential therapeutic application of [leflunomide] in [dengue virus infection]. The research, like a beacon of hope in the vast desert, shines light on a potential new treatment strategy for this debilitating disease. Further research is needed to fully understand the efficacy and safety of [leflunomide] in this context, but the study provides a valuable starting point for developing new treatments for [dengue virus infection].
Dr.Camel's Conclusion
This research, like a wise camel navigating the dunes of [immunology], unveils a potential new weapon in the fight against [dengue virus infection]. The study's findings suggest that [leflunomide], a drug already known for its therapeutic effects in [arthritis], might also play a role in modulating the immune response to [dengue virus]. While further research is needed to confirm this potential, the study's findings are a valuable step towards developing novel therapies for this devastating disease.
Date :
- Date Completed 2012-04-13
- Date Revised 2021-12-03
Further Info :
Related Literature
English
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.