Immunosuppressive effects and mechanisms of leflunomide in dengue virus infection of human dendritic cells.

Author: ChangDeh-Ming, ChenPei-Chih, HoLing-Jun, HsuSeng-Ting, LaiJenn-Haung, TsaiYi-Ting, WuWan-Lin

Paper Details 
Original Abstract of the Article :
BACKGROUND: Dengue virus (DENV) infection is a serious public health issue without specific treatment. We examined the potential immunomodulatory effects of leflunomide, a dihydroorotate dehydrogenase inhibitor commonly prescribed for arthritis, in DENV-stimulated monocyte-derived dendritic cells (m...See full text at original site
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引用元:
https://doi.org/10.1007/s10875-011-9578-7

データ提供:米国国立医学図書館(NLM)

Leflunomide: A Potential Ally Against Dengue Virus

The world of [immunology] is continuously searching for effective treatments for [dengue virus infection], a mosquito-borne disease that poses a significant health threat worldwide. This study explores the potential of [leflunomide], a drug commonly used for [arthritis], in modulating the immune response to [dengue virus] infection.

Leflunomide: A Suppressor of Dengue Virus Immune Response

The study found that [leflunomide] effectively inhibited the production of [cytokines and chemokines] from [dendritic cells] infected with [dengue virus]. This effect was linked to the suppression of key signaling pathways, suggesting that [leflunomide] might be able to dampen the excessive immune response that can contribute to the severity of [dengue virus infection]. This is like calming a desert storm – [leflunomide] acts as a soothing agent, mitigating the harmful effects of the immune system's response to the virus.

A Potential New Weapon in the Fight Against Dengue

The study's findings offer promising insights into the potential therapeutic application of [leflunomide] in [dengue virus infection]. The research, like a beacon of hope in the vast desert, shines light on a potential new treatment strategy for this debilitating disease. Further research is needed to fully understand the efficacy and safety of [leflunomide] in this context, but the study provides a valuable starting point for developing new treatments for [dengue virus infection].

Dr.Camel's Conclusion

This research, like a wise camel navigating the dunes of [immunology], unveils a potential new weapon in the fight against [dengue virus infection]. The study's findings suggest that [leflunomide], a drug already known for its therapeutic effects in [arthritis], might also play a role in modulating the immune response to [dengue virus]. While further research is needed to confirm this potential, the study's findings are a valuable step towards developing novel therapies for this devastating disease.

Date :
  1. Date Completed 2012-04-13
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

21845515

DOI: Digital Object Identifier

10.1007/s10875-011-9578-7

Related Literature

SNS
PICO Info
in preparation
Languages

English

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