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Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration.

Author: ElsworthJohn D, GromanStephanie M, JentschJ David, MarstonHugh, RothRobert H, ShahidMohammed, VallesRodrigo, WongErik

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Asenapine, an atypical antipsychotic, showed cognitive and motor improvement in monkeys previously exposed to PCP, a model of schizophrenia. It also normalized dopamine and serotonin turnover in specific brain regions. This suggests that asenapine may have potential benefits for treating cognitive dysfunction in schizophrenia.
Paper Details　
Original Abstract of the Article :
Repeated, intermittent administration of the psychotropic NMDA antagonist phencyclidine (PCP) to laboratory animals causes impairment in cognitive and executive functions, modeling important sequelae of schizophrenia; these effects are thought to be due to a dysregulation of neurotransmission within...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/21875607

データ提供：米国国立医学図書館（NLM）

Asenapine: Navigating the Sandstorms of Schizophrenia

This study explores the effects of asenapine, a medication used to treat schizophrenia, a mental health disorder that can disrupt cognitive functions and neurotransmitter balance. Imagine a desert with a constantly shifting sandstorm that hinders visibility and communication. The researchers investigated how asenapine might help clear the sandstorms and restore clarity in the brain.

Restoring Clarity in the Brain

The researchers found that asenapine had positive effects on cognitive function and neurotransmitter levels in monkeys, which are like a miniature desert ecosystem where we can study these effects. This is like discovering a new method to manage the sandstorms, allowing the desert to thrive again.

A New Oasis in the Desert of Mental Health

This study offers hope for individuals with schizophrenia. The researchers believe that asenapine could be a valuable tool for managing symptoms and improving quality of life. This is like building a sustainable oasis in the desert, providing refuge and resources for those facing mental health challenges.

Dr. Camel's Conclusion

This study, like a camel caravan navigating a treacherous desert, reveals a potential path for improving cognitive function and neurotransmitter balance in individuals with schizophrenia. Asenapine, like a well-stocked oasis, provides hope for restoring clarity and alleviating the debilitating effects of this complex mental health disorder.
Date :
  1. Date Completed 2012-09-27
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

21875607

DOI: Digital Object Identifier

NIHMS483350

Related Literature

Article Analysis
・Effects of asenapine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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