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Multivariable model for time to first treatment in patients with chronic lymphocytic leukemia.

Author: AbruzzoLynne, BurgerJan A, CortesJorge, DoKim-Anh, FaderlStefan, FerrajoliAlessandra, Garcia-ManeroGuillermo, KantarjianHagop M, KeatingMichael J, KollerCharles A, LernerSusan, O'BrienSusan, SchletteEllen, ThomasDeborah, WangXuemei, WierdaWilliam G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Chronic lymphocytic leukemia (CLL) affects people differently, with some experiencing a slow progression that doesn't require treatment, while others have a more aggressive form that needs early intervention. This study identifies factors that predict when people with CLL will need treatment by analyzing the factors associated with time until treatment initiation.
Paper Details　
Original Abstract of the Article :
The clinical course for patients with chronic lymphocytic leukemia (CLL) is diverse; some patients have indolent disease, never needing treatment, whereas others have aggressive disease requiring early treatment. We continue to use criteria for active disease to initiate therapy. Multivariable analy...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876352/

データ提供：米国国立医学図書館（NLM）

Predicting Treatment Initiation in Chronic Lymphocytic Leukemia: A Desert of Diverse Clinical Courses

Chronic lymphocytic leukemia (CLL) is a type of cancer affecting white blood cells. This study explores the factors that influence the timing of treatment initiation in patients with CLL, recognizing that the disease can have a wide range of clinical courses. The researchers conducted multivariable analysis to identify prognostic factors independently associated with time to first treatment.

Factors Influencing Treatment Initiation in CLL: Navigating the Uncertainties of Cancer Management

The study identified several factors independently associated with time to first treatment, including age, stage, and the presence of specific genetic markers. These findings provide valuable insights into the factors that contribute to the diverse clinical courses of CLL, helping clinicians to better predict and manage the disease.

Understanding the Landscape of CLL: A Guide for Personalized Care

This research is like a journey through the desert of CLL, where understanding the diverse clinical presentations and identifying factors that influence treatment timing is crucial. The findings underscore the importance of personalized care, allowing clinicians to tailor treatment strategies based on individual patient characteristics and prognostic factors. This research serves as a valuable resource for healthcare professionals navigating the complex landscape of CLL management, helping to ensure that patients receive the most appropriate care.

Dr.Camel's Conclusion

This study examines the factors influencing treatment initiation in chronic lymphocytic leukemia (CLL), highlighting the diverse clinical courses of the disease. The identification of prognostic factors associated with time to first treatment provides valuable insights for personalized care, allowing clinicians to tailor treatment strategies and improve patient outcomes. This research is like a guide through the desert of CLL, providing a map to navigate the uncertainties of cancer management and ensure that patients receive the most appropriate care.

Date :
  1. Date Completed 2011-12-20
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

21969505

DOI: Digital Object Identifier

PMC4876352

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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