Paper Details

  1. Home
  2. Paper Details

Transfer of interferon β-1a into human breastmilk.

Author: BakerTeresa E, HaleThomas W, SiddiquiAfzal A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study measured interferon β-1a levels in human milk samples from six women receiving intramuscular interferon β-1a. The estimated relative infant dose was 0.006% of the maternal dose, suggesting that interferon β-1a does not penetrate the milk compartment significantly.
Paper Details　
Original Abstract of the Article :
AIM: This study determined the transfer of intramuscular interferon β-1a into human milk and provides an estimate of infant exposure to this antiviral in six women chronically receiving intramuscular interferon β-1a (Avonex(®), Biogen Idec, Research Triangle Park, NC). METHODS: Interferon β-1a was ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1089/bfm.2011.0044

データ提供：米国国立医学図書館（NLM）

A Journey Through the Labyrinth of Interferon Beta-1a Transfer

The human body is a complex labyrinth, with intricate pathways and delicate balances. This study delves into the world of

pharmacology, exploring the journey of a medication called interferon beta-1a through the maternal system, specifically its transfer into breast milk. Interferon beta-1a, a drug commonly used to treat multiple sclerosis, was administered intramuscularly to six women, and researchers meticulously tracked its presence in their breast milk. The study sought to quantify the amount of interferon beta-1a transferred into the milk and estimate the potential exposure of a nursing infant to this antiviral drug.

A Tale of Two Compartments: Maternal System and Breast Milk

The results of this study demonstrate that interferon beta-1a does not readily penetrate the breast milk compartment. The concentration of the drug in breast milk was significantly lower than in the maternal system. The estimated relative infant dose was a mere 0.006% of the maternal dose, suggesting a minimal risk of exposure to the nursing infant. Moreover, no side effects were observed in the breastfed infants.

The Importance of Understanding Drug Transfer

This study provides valuable insight into the pharmacokinetic properties of interferon beta-1a. It highlights the importance of understanding how medications are transferred through the body, particularly in the context of breastfeeding. This knowledge can help healthcare professionals make informed decisions about medication use during lactation, ensuring the safety of both mother and child.

Dr. Camel's Conclusion

The human body is a complex labyrinth, and drugs can travel through it in fascinating ways. This study provides evidence that interferon beta-1a, a vital medication for treating multiple sclerosis, does not significantly transfer into breast milk. This finding offers reassurance to mothers who are using this medication and want to breastfeed, knowing that the risk of exposure to their infants is minimal.

Date :
  1. Date Completed 2012-06-25
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

21988602

DOI: Digital Object Identifier

10.1089/bfm.2011.0044

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.