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Subcutaneous methylnaltrexone for treatment of acute opioid-induced constipation: phase 2 study in rehabilitation after orthopedic surgery.

Author: AnissianLucas, CarpenitoJennifer, RamakrishnaTage, SchwartzHarry W, StamblerNancy, VincentHeather K, VincentKevin

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Subcutaneous methylnaltrexone was effective and well tolerated in treating acute opioid-induced constipation (OIC) after orthopedic procedures. Patients receiving methylnaltrexone achieved laxation significantly faster than those receiving placebo.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Methylnaltrexone has been shown to be effective for treating opioid-induced constipation (OIC) in chronic settings, but its effects on acute OIC have not been studied. OBJECTIVE: To assess safety and efficacy of subcutaneous methylnaltrexone in patients with acute OIC after orthopedic p...See full text at original site
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引用元：
https://doi.org/10.1002/jhm.943

データ提供：米国国立医学図書館（NLM）

Methylnaltrexone: A Relief in the Desert of Opioid-Induced Constipation

Opioid-induced constipation (OIC) is a common and uncomfortable side effect of opioid medication, often described as a harsh desert of discomfort. This study investigates the effectiveness of subcutaneous methylnaltrexone for treating acute OIC in patients recovering from orthopedic surgery. The researchers conducted a phase 2 clinical trial to assess the safety and efficacy of methylnaltrexone for relieving OIC in this specific population.

Methylnaltrexone: A Refreshing Oasis

The study found that methylnaltrexone was effective in inducing laxation and significantly shortened the time to laxation compared to placebo. This suggests that methylnaltrexone could be a valuable tool for managing acute OIC in patients recovering from orthopedic surgery. Imagine a traveler in a harsh desert, desperate for a source of water. Methylnaltrexone could be like a refreshing oasis, providing relief from the discomfort and dehydration caused by OIC.

Navigating the Desert of OIC

This research provides promising evidence for the effectiveness of methylnaltrexone in treating acute OIC. Further research is needed to confirm these findings and assess the long-term effectiveness and safety of this treatment approach. As we continue to explore the desert of OIC research, we need to find innovative ways to alleviate the discomfort and improve the quality of life for patients experiencing this side effect.

Dr.Camel's Conclusion

Methylnaltrexone could offer a refreshing oasis in the desert of OIC, providing relief for those experiencing this common side effect of opioid medication. While further research is needed to solidify its effectiveness, this study suggests that it could be a valuable tool for improving the comfort and recovery of patients experiencing acute OIC.

Date :
  1. Date Completed 2012-09-21
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

21998076

DOI: Digital Object Identifier

10.1002/jhm.943

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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