Developmental outcome after exposure to cyclooxygenase inhibitors during pregnancy and lactation.

Author: BurdanFranciszek, ChalasAnna, KlepaczRobert, Pliszczynska-SteudenMalgorzata, RozyloT Katarzyna, Rozylo-KalinowskaIngrid, StaroslawskaElzbieta, SzumiloJustyna

Paper Details 
Original Abstract of the Article :
The developmental toxicity of non-selective (ibuprofen, piroxicam, tolmetin) and selective cyclooxygenase-2 inhibitors (DFU) was evaluated in rats. Compounds were administered separately from the eighth gestational to the seventh lactational day. After spontaneous delivery, the weight, length and nu...See full text at original site
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引用元:
https://doi.org/10.1016/j.reprotox.2011.09.012

データ提供:米国国立医学図書館(NLM)

Cyclooxygenase Inhibitors: Navigating the Desert of Developmental Toxicity

Imagine a delicate desert ecosystem, where the survival of offspring depends on the careful balance of environmental factors. This research explores the potential developmental toxicity of cyclooxygenase inhibitors, a class of drugs commonly used to treat pain and inflammation. The researchers investigated the impact of these drugs on rat fetuses and pups, seeking to understand the potential risks associated with exposure during pregnancy and lactation.

A Journey Through the Desert of Development: Understanding the Risks

The research revealed that non-selective cyclooxygenase inhibitors (NSAIDs) could affect pup growth and bone mineralization, highlighting the need for caution when using these medications during pregnancy and lactation. It's like discovering a hidden danger in the desert, where certain resources can have unintended consequences. The researchers observed a decrease in pup weight and length, and alterations in bone density, underscoring the importance of carefully weighing the risks and benefits of NSAID use during these critical periods.

A Call for Vigilance: Protecting the Next Generation

This research emphasizes the importance of understanding the potential developmental toxicity of medications and the need for careful consideration when using drugs during pregnancy and lactation. It's like navigating a challenging desert landscape, where awareness and caution are essential for protecting the vulnerable. The researchers encourage further research into the effects of NSAIDs and other medications on fetal and postnatal development, striving to ensure the safety and well-being of future generations.

Dr.Camel's Conclusion

This research highlights the importance of carefully considering the potential effects of medications on fetal and postnatal development. It's like navigating a vast desert, where knowledge and caution are essential for ensuring the health and well-being of future generations. By understanding the potential risks and benefits of medication use, we can make informed decisions that protect the health and development of both mothers and their children.

Date :
  1. Date Completed 2012-04-06
  2. Date Revised 2011-11-28
Further Info :

Pubmed ID

22005020

DOI: Digital Object Identifier

10.1016/j.reprotox.2011.09.012

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