The cytotoxic effects of bendamustine in combination with cytarabine in mantle cell lymphoma cell lines.

Author: AlbieroElena, BernardiMartina, CastegnaroSilvia, ChieregatoKatia, MadeoDomenico, RodeghieroFrancesco, ViscoCarlo, ZanonCristina

Paper Details 
Original Abstract of the Article :
Bendamustine is clinically useful in mantle-cell lymphoma (MCL). Its favorable toxicity profile in-vivo favors its combination with other cytotoxic drugs. Cytarabine is a key drug in the treatment of younger patients with MCL. The current study investigated the in-vitro cytotoxic effect of bendamust...See full text at original site
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引用元:
https://doi.org/10.1016/j.bcmd.2011.09.007

データ提供:米国国立医学図書館(NLM)

Combating Mantle Cell Lymphoma: A Synergistic Approach

The field of [mantle cell lymphoma (MCL) treatment] seeks to develop effective therapies to combat this aggressive type of cancer. This study investigates the [cytotoxic effects] of two drugs, [bendamustine] and [cytarabine], when used alone and in combination. The researchers explored the synergistic potential of these drugs in two MCL cell lines, representing the classic and blastoid variants of the lymphoma subtype. The study found that the combination of bendamustine and cytarabine, particularly when administered consecutively, exhibited a [strong synergistic effect] in inducing apoptosis and inhibiting cell proliferation. This finding suggests that combining these drugs may be a more effective approach to treating MCL compared to using either drug alone.

A Synergistic Approach: Combining Forces Against Mantle Cell Lymphoma

The study's findings suggest that combining [bendamustine] and [cytarabine] may be a powerful approach to combating MCL. The synergistic effects observed in this study offer a potential avenue for improving treatment outcomes.

Mantle Cell Lymphoma: A Journey Through the Desert of Cancer

Cancer treatment often involves navigating a vast and challenging landscape, with a constant search for effective therapies. This study explores the potential of [bendamustine] and [cytarabine] as powerful allies in the fight against MCL. The synergistic effects of these drugs offer a glimmer of hope for patients seeking effective treatments.

Dr. Camel's Conclusion

This study is a journey through the heart of a complex medical problem. It highlights the potential of combining [bendamustine] and [cytarabine] to effectively treat MCL. This synergistic approach offers a new and promising avenue for improving patient outcomes. Like a camel traversing a vast and unforgiving desert, we must constantly adapt and innovate to find the most effective solutions to combat this challenging disease.

Date :
  1. Date Completed 2012-09-13
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

22036761

DOI: Digital Object Identifier

10.1016/j.bcmd.2011.09.007

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