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Serum markers associated with clinical improvement in patients with ankylosing spondylitis treated with golimumab.

Author: BraunJürgen, DeodharAtul, ElashoffMichael, HsuBenjamin, InmanRobert D, MackMichael, VisvanathanSudha, WagnerCarrie, van der HeijdeDésirée

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Golimumab treatment for ankylosing spondylitis (AS) modulated acute phase reactants and inflammatory markers, resulting in a distinct biomarker profile in patients achieving clinical response. Specific combinations of biomarkers at baseline were more predictive of clinical efficacy than C-reactive protein (CRP) alone.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Identify serum biomarkers modulated by golimumab treatment and associated with clinical response in patients with ankylosing spondylitis (AS). METHODS: Sera were collected at weeks 0, 4 and 14 from 100 patients with active AS in the GO-RAISE study. Patients were randomly assigned subcuta...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329231/

データ提供：米国国立医学図書館（NLM）

Golimumab: A Biomarker-Guided Approach to Ankylosing Spondylitis

Ankylosing spondylitis (AS), a chronic inflammatory disease affecting the spine, poses a significant challenge for treatment. This study investigates the impact of golimumab, a biologic drug used to treat AS, on specific serum biomarkers and their association with clinical response. The researchers examined changes in various inflammatory, bone, and cartilage markers in patients with AS who received golimumab treatment. This research provides a deeper understanding of golimumab's mechanism of action and its potential for personalized treatment strategies.

Golimumab: A Targeted Approach to Ankylosing Spondylitis

The study found that golimumab treatment significantly decreased various serum proteins associated with inflammation, suggesting that it effectively targets the underlying inflammatory processes in AS. The researchers also identified specific combinations of biomarkers that effectively predicted clinical outcomes, offering a potential for personalized treatment strategies based on individual biomarker profiles.

Precision Medicine: A New Frontier for Ankylosing Spondylitis Treatment

This study opens up exciting possibilities for precision medicine in the treatment of AS. By using biomarker-guided approaches, doctors can tailor treatment plans to individual patients, potentially improving outcomes and minimizing adverse effects. This research highlights the potential of precision medicine to revolutionize the treatment of chronic inflammatory diseases.

Dr. Camel's Conclusion

The findings of this study offer a glimpse into the future of AS treatment. By understanding the complex interplay between golimumab, biomarkers, and clinical response, we can develop personalized treatment strategies that are more effective and targeted than ever before.

Date :
  1. Date Completed 2012-05-31
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

22039165

DOI: Digital Object Identifier

PMC3329231

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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