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Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.

Author: HosokawaR, IidaT, InagakiT, InenagaK, OnoK, Wakasugi-SatoN

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the comprehensive effects of cevimeline and pilocarpine, muscarinic receptor agonists, on salivary, cardiovascular, and central mechanisms in rats. These drugs are used as sialogogues for xerostomia treatment.
Paper Details　
Original Abstract of the Article :
Cevimeline and pilocarpine (muscarinic receptor agonists) are used as sialogogues in xerostomia treatment. It is important to know the different effects on their salivary mechanisms and the side effects. The aim of the present study was to clarify and compare the comprehensive effects of cevimeline ...See full text at original site
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引用元：
https://doi.org/10.1016/j.archoralbio.2011.09.013

データ提供：米国国立医学図書館（NLM）

Cevimeline and Pilocarpine: A Comparative Study of Salivary Stimulants

This study delves into the intriguing world of salivary stimulants, focusing on cevimeline and pilocarpine, two muscarinic receptor agonists commonly used to treat xerostomia (dry mouth). The researchers compared the effects of these drugs on salivary mechanisms, cardiovascular response, and thirst sensation in rats. Their findings revealed distinct differences between the two drugs, highlighting the importance of selecting the appropriate medication based on individual needs and potential side effects.

Cevimeline and Pilocarpine: A Tailored Approach to Treating Dry Mouth

This study underscores the importance of a tailored approach to treating dry mouth. The researchers found that cevimeline and pilocarpine, while both effective salivary stimulants, have distinct effects on the body. Choosing the appropriate drug based on an individual's specific needs and potential side effects is crucial.

Understanding the Mechanisms of Dry Mouth

This study provides valuable insights into the mechanisms of dry mouth and the impact of different salivary stimulants. Understanding these mechanisms is crucial for developing more effective and targeted treatments for this common condition.

Dr.Camel's Conclusion

This study highlights the nuanced differences between cevimeline and pilocarpine as salivary stimulants. Choosing the right drug for an individual depends on their specific needs and potential side effects. The research emphasizes the importance of personalized medicine, considering individual factors to optimize treatment outcomes.

Date :
  1. Date Completed 2012-08-02
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

22099058

DOI: Digital Object Identifier

10.1016/j.archoralbio.2011.09.013

Related Literature

Article Analysis
・Side Effects of cevimeline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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