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Use of aliskiren in a 'real-life' model of hypertension management: analysis of national Web-based drug-monitoring system in Italy.

Author: , BianchiniFrancesca, CovezzoliAnna, De RosaMarisa, FedozziElisabetta, MaggioniAldo P, TocciGiuliano, VolpeMassimo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

In a group of high cardiovascular risk patients with uncontrolled blood pressure, aliskiren (150-300 mg daily) added to existing antihypertensive drugs lowered blood pressure significantly. The blood pressure levels at 6 months were lower than at baseline, with a very low rate of reported side-effects.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: In Italy, prescriptions of the direct renin inhibitor aliskiren (aliskiren) to high-risk hypertensive patients must be electronically filled by specialized physicians only when at least two antihypertensive drug classes (independently of the dosages), fails to normalize blood pressure ...See full text at original site
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引用元：
https://doi.org/10.1097/HJH.0b013e32834e1c66

データ提供：米国国立医学図書館（NLM）

Aliskiren's Real-World Effectiveness in Hypertension Management

This study delves into the realm of cardiology, specifically investigating the real-world effectiveness of aliskiren, a direct renin inhibitor, in managing hypertension. The researchers utilized a national Web-based drug-monitoring system in Italy to analyze the effects of adding aliskiren to existing antihypertensive therapies in high-risk hypertensive patients. The study observed a consistent reduction in blood pressure (BP) levels among patients receiving aliskiren, accompanied by a decrease in the use of other antihypertensive drugs. These findings suggest that aliskiren may be a valuable addition to the management of hypertension in high-risk patients with uncontrolled BP.

Aliskiren: A Promising Tool for Hypertension Management

The study's results provide evidence for the real-world effectiveness of aliskiren in lowering BP levels, particularly in patients with uncontrolled hypertension and a high cardiovascular risk. This information could inform clinical practice and encourage the wider use of aliskiren in managing this prevalent condition.

Controlling Blood Pressure: A Journey Through the Cardiovascular System

As a cardiologist, I am constantly seeking ways to optimize the management of hypertension. This study highlights the potential of aliskiren as a valuable tool for controlling BP, particularly in patients who have not responded well to other therapies. This research reminds me of navigating a vast desert, where each step toward controlling BP is crucial in ensuring the well-being of our patients.

Dr.Camel's Conclusion

This study provides real-world evidence supporting the efficacy of aliskiren in lowering BP levels in high-risk hypertensive patients. The observed reduction in BP and concomitant decrease in the use of other antihypertensive drugs suggest that aliskiren could play a significant role in optimizing hypertension management strategies.
Date :
  1. Date Completed 2012-04-03
  2. Date Revised 2012-11-15
Further Info :

Pubmed ID

22157325

DOI: Digital Object Identifier

10.1097/HJH.0b013e32834e1c66

Related Literature

Article Analysis
・Side Effects of aliskiren
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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