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Original Abstract of the Article :
Because of the central role of platelets in cardiovascular atherothrombosis, there is a well-established therapeutic role for antiplatelet therapy that includes aspirin (a cyclooxygenase 1 [COX1] inhibitor), clopidogrel (an antagonist of the ADP P2Y(12) receptor), and the GPIIb-GPIIIa (αIIbβ3) antag...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1182/asheducation-2011.1.62
データ提供:米国国立医学図書館(NLM)
Antiplatelet Therapy: A Race Against Time in the Desert of Atherosclerosis
This review discusses advancements in antiplatelet therapy, focusing on the crucial role of platelets in cardiovascular atherothrombosis. While current antiplatelet agents like aspirin and clopidogrel have proven effective, there remains a significant incidence of arterial thrombosis in patients. The review highlights the emergence of novel P2Y(12) antagonists, such as prasugrel, ticagrelor, cangrelor, and elinogrel, which offer advantages over clopidogrel. These newer agents exhibit faster, more consistent, and complete inhibition of platelet function. The review also explores the potential of thrombin receptor protease-activated receptor 1 (PAR1) antagonists and other novel antiplatelet agents currently under investigation.
Antiplatelet Therapy: A Race Against Time in the Desert of Atherosclerosis
The battle against cardiovascular disease is a continuous race against time, much like a journey across a vast desert where each step forward requires careful consideration. This review highlights the ongoing efforts to develop more effective antiplatelet therapies, aiming to prevent devastating events like heart attacks and strokes. By understanding the mechanisms of platelet aggregation and developing novel inhibitors, researchers are working to pave the way for a safer and more effective approach to cardiovascular disease management.
Navigating the Sands of Cardiovascular Health
Cardiovascular disease is a major public health concern, affecting millions worldwide. Understanding the latest advancements in antiplatelet therapy is critical for preventing and managing this condition. Imagine a desert traveler equipped with a map, a compass, and a reliable vehicle, navigating the treacherous terrain with confidence. Similarly, by staying informed about advancements in antiplatelet therapy, individuals can enhance their cardiovascular health and navigate the journey to a healthier life.
Dr.Camel's Conclusion
This comprehensive review highlights the exciting progress being made in antiplatelet therapy. The development of novel agents with improved efficacy and safety profiles offers hope for reducing the burden of cardiovascular disease. The quest for better treatments is like a relentless expedition across a vast and unforgiving desert, but with dedication and innovation, we can find new ways to conquer this formidable challenge.
Date :
- Date Completed 2012-04-04
- Date Revised 2016-10-21
Further Info :
Related Literature
English
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