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Impact of statin dose on major cardiovascular events: a mixed treatment comparison meta-analysis involving more than 175,000 patients.

Author: DuncanBruce Bartholow, MoriguchiEmílio Hideyuki, PolanczykCarisi Anne, RestelattoLuciane Maria Fabian, RibeiroRodrigo Antonini, StellaSteffan Frosi, ZiegelmannPatricia Klarmann, da Costa VieiraJosé Luiz

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study compared different statin doses for reducing cardiovascular events and deaths through mixed treatment comparisons. The results suggest that higher doses of statins are associated with greater benefits.
Paper Details　
Original Abstract of the Article :
The benefit of statins in the reduction of cardiovascular events was demonstrated in several placebo-controlled trials. More intensive therapy seems to be associated with greater benefit. Our objective was to compare different statin doses in the reduction of cardiovascular events and deaths, combin...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijcard.2011.10.128

データ提供：米国国立医学図書館（NLM）

Statin Doses: Finding the Right Balance for Cardiovascular Health

Statins, a class of drugs used to lower cholesterol levels, have been proven effective in reducing cardiovascular events. This meta-analysis, involving over 175,000 patients, aimed to compare the impact of different statin doses on cardiovascular outcomes. The researchers combined direct and indirect evidence to assess the effectiveness of various statin doses in reducing cardiovascular events and deaths. The analysis revealed that more intensive statin therapy was associated with greater benefits in reducing cardiovascular events. It's like finding the optimal path through a desert of varying statin doses to reach a destination of improved cardiovascular health.

Statin Therapy: A Balancing Act for Cardiovascular Protection

This meta-analysis provides valuable insights into the relationship between statin dose and cardiovascular outcomes. The findings suggest that higher statin doses can significantly reduce cardiovascular events, but it's important to note that the optimal dose varies based on individual factors. It's like navigating a desert with a map that guides you to the best routes, but you still need to adapt to the changing terrain and choose the path that suits your needs.

Protecting Your Heart: Lifestyle Modifications and Personalized Statin Therapy

This research emphasizes the importance of a personalized approach to statin therapy, taking into account individual risk factors and cardiovascular goals. It also highlights the role of lifestyle modifications, such as diet and exercise, in improving cardiovascular health. Just as a camel adapts to survive in a harsh desert environment, we need to adopt healthy habits and work with our healthcare providers to optimize our cardiovascular well-being.

Dr.Camel's Conclusion

Finding the right statin dose is like discovering a hidden spring in the vast desert of cardiovascular health. This meta-analysis provides valuable guidance for doctors and patients, emphasizing the importance of a personalized approach to statin therapy. It's a reminder that cardiovascular health requires a multifaceted approach, combining medication, lifestyle changes, and regular monitoring.

Date :
  1. Date Completed 2014-02-13
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

22192281

DOI: Digital Object Identifier

10.1016/j.ijcard.2011.10.128

Related Literature

Article Analysis
・Effective treatment of statins
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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