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Comparison of risperidone oral solution and intramuscular haloperidol with the latter shifting to oral therapy for the treatment of acute agitation in patients with schizophrenia.

Author: ChenHonghui, FangMaosheng, HuangJizhong, LiLe-Hua, LiYi, LiuLianzhong, WangBo, WangGang, WuRenrong, YeMeng, ZhangLulu, ZhangQinge, ZhaoJing-Ping, ZhengHongbo, ZhouJianchu, ZhuSuoyu

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Risperidone oral solution (RIS-OS) combined with clonazepam was as effective as intramuscular haloperidol in treating acute agitation in patients with schizophrenia. RIS-OS was associated with fewer extrapyramidal symptoms.
Paper Details　
Original Abstract of the Article :
This randomized, parallel-group, open study investigated the efficacy and safety of risperidone oral solution (RIS-OS) in combination with clonazepam and intramuscular haloperidol for the treatment of acute agitation in patients with schizophrenia, and the study explored the possibility of decreasin...See full text at original site
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引用元：
https://doi.org/10.1097/YIC.0b013e32834fc431

データ提供：米国国立医学図書館（NLM）

A Comparative Study of Risperidone Oral Solution and Haloperidol in Treating Schizophrenia

In the realm of psychiatric treatment, this study provides a comparative analysis of risperidone oral solution (RIS-OS) and intramuscular haloperidol, both used to manage acute agitation in patients with schizophrenia.

The Quest for Effective Treatment

The researchers conducted a randomized, open study involving 205 patients with schizophrenia experiencing acute agitation. They aimed to determine the efficacy and safety of RIS-OS in combination with clonazepam compared to intramuscular haloperidol.

Key Findings and Implications

The study discovered that both RIS-OS and haloperidol were effective in reducing agitation, with similar efficacy after 5 days of treatment. The oral treatment demonstrated greater efficacy in reducing extrapyramidal symptoms, a significant advantage for patients.

Health Implications and Treatment Choices

These findings suggest that RIS-OS, when combined with clonazepam, offers a viable and well-tolerated alternative to intramuscular haloperidol for managing acute agitation in schizophrenia.

Dr.Camel's Conclusion

Imagine a vast desert with two paths leading to a distant oasis. This study helps us choose the path that is not only effective but also provides a smoother journey, reducing the risk of side effects along the way.
Date :
  1. Date Completed 2012-06-04
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

22233697

DOI: Digital Object Identifier

10.1097/YIC.0b013e32834fc431

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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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