Paper Details

  1. Home
  2. Paper Details

Loperamide, an FDA-approved antidiarrhea drug, effectively reverses the resistance of multidrug resistant MCF-7/MDR1 human breast cancer cells to doxorubicin-induced cytotoxicity.

Author: GuXinbin, ShaWei, ShanLiang, SridharRajagopalan, SukumarSaraswati, ZhouYanfei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Loperamide, an FDA-approved antidiarrheal drug, significantly enhanced the cytotoxicity of doxorubicin to MCF-7/MDR1 cells, which are resistant to doxorubicin. This suggests loperamide may be beneficial in treating patients with multidrug-resistant tumors.
Paper Details　
Original Abstract of the Article :
Loperamide is an FDA-approved antidiarrhea drug which acts on the μ-opioid receptors in the mesenteric plexus of large intestine and exhibits limited side effects. We hypothesized that loperamide might reverse the multidrug resistance (MDR) of human cancer cells to chemotherapeutic agents. MCF-7/MDR...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/22250587

データ提供：米国国立医学図書館（NLM）

Loperamide: A Potential Weapon Against Multidrug Resistance in Breast Cancer

Multidrug resistance (MDR) is a major challenge in cancer treatment, as it can make cancer cells resistant to chemotherapy drugs. This study explores the potential of loperamide, a commonly used antidiarrhea medication, to overcome MDR in human breast cancer cells. The researchers investigated the effects of loperamide on the cytotoxicity of doxorubicin, a common chemotherapy drug, in MCF-7/MDR1 cells, which are known to be resistant to doxorubicin. They found that loperamide significantly enhanced the cytotoxicity of doxorubicin in these cells, suggesting that loperamide could potentially be used to overcome MDR and improve the effectiveness of chemotherapy in treating breast cancer.

Breaking Down Resistance: A New Approach to Cancer Treatment

The study's findings offer a glimmer of hope for overcoming MDR in breast cancer. The researchers' discovery that loperamide can enhance the efficacy of doxorubicin in resistant cells opens up new possibilities for developing strategies to combat MDR and improve patient outcomes. This research highlights the importance of exploring novel drug combinations to improve cancer treatment and potentially save lives.

Combating Cancer: A Multifaceted Approach

Cancer treatment is an ongoing battle, and researchers are constantly searching for new ways to fight this disease. This study underscores the importance of exploring novel treatment strategies, including repurposing existing drugs, to overcome challenges like MDR and improve patient outcomes. By embracing a multifaceted approach to cancer treatment, we can work towards a future where cancer is no longer a death sentence.

Dr.Camel's Conclusion

Just as a camel can endure harsh conditions and navigate challenging terrains, cancer researchers are constantly exploring new approaches to combat this formidable disease. This study highlights the potential of repurposing existing drugs like loperamide to overcome MDR and improve the efficacy of chemotherapy. By staying vigilant and embracing innovative strategies, we can make significant strides in the fight against cancer.

Date :
  1. Date Completed 2012-05-22
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22250587

DOI: Digital Object Identifier

NIHMS359985

Related Literature

Article Analysis
・Side Effects of loperamide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.