Paper Details

  1. Home
  2. Paper Details

Effects of the NK1 antagonist, aprepitant, on response to oral and intranasal oxycodone in prescription opioid abusers.

Author: HeiligMarkus, HendersonPam, LofwallMichelle R, NuzzoPaul A, WalshSharon L

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Aprepitant, an NK1 receptor antagonist, significantly enhanced the subjective effects of oxycodone, including euphoria and liking, when administered as a pre-treatment. This effect was observed with both oral and intranasal routes of oxycodone administration. All dose combinations were safely tolerated.
Paper Details　
Original Abstract of the Article :
Pre-clinical studies suggest that the neurokinin-1 (NK1) receptor may modulate the response to opioids, with NK(1) inactivation leading to decreased opioid reinforcement, tolerance and withdrawal. Aprepitant is a selective NK1 antagonist currently marketed for clinical use as an anti-emetic. This 6-...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/22260216

データ提供：米国国立医学図書館（NLM）

Aprepitant: A Potential Catalyst for Opioid Abuse? Exploring the Interactions

Opioid abuse is a complex issue, and understanding how different drugs interact with opioids is critical for addressing this problem. Imagine a desert traveler encountering a mirage, only to discover a hidden well of addiction. This study explores the effects of aprepitant, an anti-emetic drug, on the response to oxycodone, a prescription opioid.

Aprepitant and Oxycodone: A Complicated Relationship in the Desert of Addiction

The study found that pre-treatment with aprepitant (200 mg) significantly enhanced ratings of oxycodone's subjective effects related to euphoria and liking, potentially increasing the risk of abuse. This finding is concerning, as it suggests that aprepitant could inadvertently exacerbate opioid abuse. It's like adding fuel to the fire of addiction, creating a dangerous situation.

Understanding Drug Interactions: Navigating the Desert of Opioid Abuse

This study highlights the importance of understanding drug interactions, particularly when it comes to opioids. Healthcare professionals must be aware of the potential for aprepitant to enhance opioid-related euphoria and liking, potentially increasing the risk of abuse. Further research is needed to clarify these interactions and develop strategies to mitigate potential risks.

Dr.Camel's Conclusion

This study raises concerns about the potential for aprepitant to enhance opioid-related euphoria and liking, potentially increasing the risk of abuse. Further research is needed to understand these interactions and develop safer treatment strategies for opioid use disorders.

Date :
  1. Date Completed 2013-09-18
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22260216

DOI: Digital Object Identifier

NIHMS666927

Related Literature

Article Analysis
・Effects of aprepitant
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.