Subjective, cognitive and cardiovascular dose-effect profile of nabilone and dronabinol in marijuana smokers.

Author: BediGillinder, CooperZiva D, HaneyMargaret

Paper Details 
Original Abstract of the Article :
Marijuana dependence is a substantial public health problem, with existing treatments showing limited efficacy. In laboratory and clinical studies, the cannabinoid receptor 1 agonist oral Δ9tetrahydrocannabinol (THC; dronabinol) has been shown to decrease marijuana withdrawal but not relapse. Dronab...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/22260337

データ提供:米国国立医学図書館(NLM)

Nabilone and Dronabinol: Navigating the Desert of Marijuana Dependence

Marijuana dependence, a widespread condition affecting millions worldwide, is like a treacherous desert, where cravings and withdrawal symptoms can trap individuals in a cycle of addiction. This study, published in 2012, investigates the effects of nabilone and dronabinol, two synthetic cannabinoid receptor 1 agonists, on marijuana smokers. The researchers, like skilled desert explorers, sought to understand the behavioral and physiological effects of these medications, hoping to find a way to escape the desert of dependence.

Exploring a New Path

The study involved 14 marijuana smokers who received various doses of nabilone, dronabinol, or placebo. The researchers carefully assessed the subjective, cognitive, and cardiovascular effects of these medications. Their findings, like a well-mapped oasis discovered after a long journey, revealed that both nabilone and dronabinol produced positive subjective effects, like a refreshing spring in the desert. Nabilone, however, had a slower onset of peak effects and was better tolerated by participants, suggesting it might be a more effective treatment for marijuana dependence.

A Promising Alternative

The study's findings, like a hidden trail leading to a fertile oasis, provide evidence for the potential of nabilone as a treatment for marijuana dependence. While further research is needed to confirm its efficacy and long-term safety, nabilone's unique characteristics, like a sturdy camel adapted to the harsh desert environment, make it a promising alternative for those struggling with marijuana addiction. It is a reminder that even in the vast and unforgiving desert of addiction, new and effective treatments can be found.

Dr. Camel's Conclusion

This study, like a beacon guiding travelers through the desert night, offers a ray of hope for individuals struggling with marijuana dependence. The promising effects of nabilone, like a hidden spring discovered in the desert, suggest a potential new path to recovery. It is a reminder that even in the most challenging landscapes, there are always opportunities for growth and healing. Just as a skilled camel guide leads a caravan safely through the desert, healthcare professionals can provide guidance and support for those seeking to break free from addiction.

Date :
  1. Date Completed 2014-03-10
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

22260337

DOI: Digital Object Identifier

NIHMS341942

Related Literature

SNS
PICO Info
in preparation
Languages

English

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