Randomized open-label drug-drug interaction trial of dextromethorphan/quinidine and paroxetine in healthy volunteers.

Author: PopeLaura E, SchoedelKerri A, SellersEdward M

Paper Details 
Original Abstract of the Article :
The novel combination of dextromethorphan (DM) and quinidine (Q) [DMQ] has been extensively studied in well controlled clinical trials as treatment for pseudobulbar affect (PBA), and is the first US Food and Drug Administration (FDA)-approved treatment for this indication. The approved dosage of DMQ...See full text at original site
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引用元:
https://doi.org/10.2165/11599870-000000000-00000

データ提供:米国国立医学図書館(NLM)

Dextromethorphan/Quinidine and Paroxetine: A Tale of Drug Interactions

Drug interactions, like unexpected encounters in a vast desert, can alter the course of treatment and pose potential risks. This study, published in the journal 'Clinical Pharmacology & Therapeutics,' investigates the potential interactions between dextromethorphan/quinidine (DMQ), a medication used to treat pseudobulbar affect (PBA), and paroxetine, an antidepressant.

Navigating the Desert of Drug Interactions: Understanding the Potential Risks

This research, like a careful traveler navigating a complex desert landscape, examines the potential interactions between DMQ and paroxetine. The study found that DMQ significantly altered the pharmacokinetics of paroxetine, highlighting the importance of considering potential drug interactions when prescribing these medications. This finding is like discovering a hidden canyon that could lead to a dangerous fall, emphasizing the need for caution.

A Call for Vigilance: The Importance of Careful Drug Management

This study underscores the importance of careful drug management and the need to consider potential interactions when prescribing medications. The findings serve as a reminder that the desert of medicine is vast and complex, and we must always be mindful of the potential impact of our actions. It's like a wise traveler carefully choosing their path to avoid unexpected obstacles.

Dr. Camel's Conclusion

This study reveals the complexities of drug interactions, reminding us that the desert of medicine is full of hidden pathways and potential hazards. The findings highlight the importance of considering these interactions to ensure patient safety and optimize treatment outcomes. This journey through the desert of medicine requires constant vigilance and careful attention to detail, ensuring the best possible care for those we serve.
Date :
  1. Date Completed 2012-06-15
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22283559

DOI: Digital Object Identifier

10.2165/11599870-000000000-00000

Related Literature

SNS
PICO Info
in preparation
Languages

English

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