Randomized pharmacodynamic and pharmacogenetic trial of dronabinol effects on colon transit in irritable bowel syndrome-diarrhea.

Author: BurtonD, CamilleriM, CarlsonP, EckertD, RyksM, WongB S, ZinsmeisterA R

Paper Details 
Original Abstract of the Article :
Genetic variation in endocannabinoid metabolism is associated with colonic transit in irritable bowel syndrome (IBS) with diarrhea (IBS-D). The nonselective cannabinoid (CB) receptor agonist, dronabinol (DRO), reduced fasting colonic motility in nonconstipated IBS. FAAH and CNR1 variants influenced ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/22288893

データ提供:米国国立医学図書館(NLM)

Unraveling the Mystery of Dronabinol's Impact on Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) with diarrhea (IBS-D) is a perplexing condition, leaving sufferers feeling like they're traversing a desert of digestive distress. This research delves into the potential benefits of dronabinol, a cannabinoid receptor agonist, in alleviating IBS-D symptoms.

The study investigates the effects of dronabinol on gut transit in IBS-D patients, examining its dose-related effects and the influence of genetic variations in cannabinoid receptor mechanisms. The findings reveal a potential connection between individual genetic makeup and the effectiveness of dronabinol in managing IBS-D symptoms.

A Potential Oasis for IBS Sufferers

The study suggests that dronabinol may be a promising treatment option for IBS-D, particularly for individuals with specific genetic variations that influence the effectiveness of cannabinoid receptor activation. The findings shed light on the intricate relationship between genetics and IBS-D, paving the way for personalized treatment approaches.

Finding Relief in the Digestive Desert

This research emphasizes the importance of understanding individual genetic predispositions and tailoring treatment strategies accordingly. It suggests that dronabinol could offer a much-needed oasis for individuals battling the discomfort and inconvenience of IBS-D.

Dr. Camel's Conclusion

This study offers a compelling exploration of the potential benefits of dronabinol in managing IBS-D, highlighting the crucial role of personalized medicine in tailoring treatment approaches to individual genetic profiles. It's a reminder that the desert of IBS-D is not devoid of hope, and with further research, we may find a path towards lasting relief.

Date :
  1. Date Completed 2012-07-30
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22288893

DOI: Digital Object Identifier

NIHMS511679

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Languages

English

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