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Combination of amlodipine plus angiotensin receptor blocker or diuretics in high-risk hypertensive patients: a 96-week efficacy and safety study.

Author: DengQing, LiuLisheng, LiuMingbo, MaLiyuan, SunHui, WangJianchun, WangWen, ZhangYuqing, ZhaoYong

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluates the long-term efficacy and safety of two antihypertensive regimens, amlodipine plus telmisartan and amlodipine plus amiloride/hydrochlorothiazide, in patients with essential hypertension and at least one cardiovascular risk factor. The study aims to address the poor blood pressure control rate and lack of established optimal combination therapy for hypertension in China.
Paper Details　
Original Abstract of the Article :
Antihypertensive therapy is effective in reducing the risk of major adverse cardiovascular events. However, blood pressure (BP) control rate remains poor and the optimal combination therapy against hypertension is not established in China. The objective of this study was to evaluate the long-term ef...See full text at original site
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引用元：
https://doi.org/10.2165/11598110-000000000-00000

データ提供：米国国立医学図書館（NLM）

Combination Therapy for Hypertension: Finding the Right Formula

The [hypertension] landscape is complex and challenging, with researchers constantly striving to find effective and safe treatment strategies. This study delves into the efficacy and safety of two combination therapies, [amlodipine plus telmisartan] and [amlodipine plus amiloride/hydrochlorothiazide], in patients with [essential hypertension] and at least one [cardiovascular risk factor]. The study, akin to a camel caravan exploring different routes across the desert, evaluated the long-term impact of these regimens. Researchers found that both combinations were effective in controlling blood pressure, highlighting the importance of personalized medicine in hypertension management.

Finding the Right Combination: Personalized Medicine for Hypertension

The results demonstrate that both combination therapies effectively controlled blood pressure in high-risk hypertensive patients. This underscores the value of tailoring antihypertensive treatment regimens to individual patient needs and risk profiles. The study emphasizes the need for continued research to refine and optimize these strategies.

Navigating the Desert of Hypertension: Finding the Right Path

The study provides valuable insights for healthcare professionals managing hypertensive patients, particularly those with multiple risk factors. Understanding the effectiveness and safety of different combination therapies is crucial for achieving optimal blood pressure control and minimizing the risk of cardiovascular events. The desert of hypertension can be navigated with the right tools and expertise.

Dr.Camel's Conclusion

This study sheds light on the efficacy and safety of two combination therapies for high-risk hypertensive patients. The findings highlight the importance of personalized medicine in hypertension management, emphasizing the need for tailored treatment regimens to achieve optimal blood pressure control and minimize the risk of cardiovascular events.

Date :
  1. Date Completed 2012-07-11
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

22329591

DOI: Digital Object Identifier

10.2165/11598110-000000000-00000

Related Literature

Article Analysis
・Effects of amiloride and hydrochlorothiazide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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