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Anti-allergic effects of nilotinib on mast cell-mediated anaphylaxis like reactions.

Author: El-AgamyDina S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effect of nilotinib, a tyrosine kinase inhibitor, on mast cell-mediated anaphylactic reactions in mice and rats. Nilotinib significantly inhibited anaphylaxis and histamine release from mast cells, suggesting its potential as an anti-allergic agent.
Paper Details　
Original Abstract of the Article :
Nilotinib is a new orally bioavailable potent tyrosine kinase inhibitor that is used for the treatment of BCR-ABL-positive chronic myelogenous leukemia. However, its effect on mast cell-mediated anaphylactic reaction is still not known. The present study aimed to investigate the effect of nilotinib ...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejphar.2012.01.039

データ提供：米国国立医学図書館（NLM）

Nilotinib: A Potential Anti-Allergic Agent

Nilotinib is a tyrosine kinase inhibitor currently used for treating BCR-ABL-positive chronic myelogenous leukemia. This study investigated the potential anti-allergic effects of nilotinib in mast cell-mediated anaphylaxis-like reactions. The researchers found that nilotinib effectively prevented systemic anaphylaxis in mice and significantly inhibited allergic paw edema in rats, suggesting that it may have anti-allergic properties.

Nilotinib Shows Anti-Allergic Potential

The study provides evidence that nilotinib may have therapeutic potential for treating allergic reactions. Its ability to inhibit mast cell-mediated anaphylaxis and allergic responses suggests that it could be a valuable addition to the arsenal of anti-allergic treatments.

Combating Allergies with Nilotinib

This study opens the door for exploring the use of nilotinib as a potential anti-allergic agent. It's like discovering a hidden oasis in the desert of allergic reactions, offering a potential therapeutic approach for individuals seeking relief from the debilitating symptoms of allergies.

Dr.Camel's Conclusion

This study offers a promising glimpse into the potential of nilotinib as an anti-allergic agent. While further research is needed to fully understand its effectiveness and safety, this study suggests that nilotinib may offer a novel therapeutic approach for managing allergic reactions.
Date :
  1. Date Completed 2012-09-13
  2. Date Revised 2022-01-14
Further Info :

Pubmed ID

22329898

DOI: Digital Object Identifier

10.1016/j.ejphar.2012.01.039

Related Literature

Article Analysis
・Effects of nilotinib
SNS
PICO Info
in preparation
Languages

English

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