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Towards safer and more predictable drug treatment--reflections from studies of the First BCPT Prize awardee.

Author: NeuvonenPertti J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

The author reviewed past studies on drug interactions. It found that bi- and trivalent cations can decrease the absorption of tetracyclines and fluoroquinolones. Some antacids increased the bioavailability of non-steroidal anti-inflammatory drugs and sulfonylureas. There were significant variations in bioavailability among different brands of phenytoin tablets. Several factors influencing the effectiveness of activated charcoal were explored, including age, disease, and drug interactions.
Paper Details　
Original Abstract of the Article :
This MiniReview is a personal recollection of selected research topics, which the author in collaboration with colleagues has studied, aiming to improve the predictability of drug therapy. In early studies, we found bi- and trivalent cations to reduce the absorption of various tetracyclines and fluo...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/j.1742-7843.2012.00858.x

データ提供：米国国立医学図書館（NLM）

Drug Interactions: Navigating the Desert of Complexities

The world of drug interactions is a complex and ever-changing landscape. This study delves into the intricate interactions of drugs, exploring various factors that can affect their effectiveness and safety. The researchers investigated the impact of different factors, such as age, diseases, and other medications, on drug pharmacokinetics and bioavailability. They highlighted the importance of understanding drug interactions to improve the predictability and safety of drug therapy.

A desert of complexities

Drug interactions are like hidden landmines in the desert of medicine, potentially leading to unintended consequences. This research, like a guidebook for navigating the complexities of drug interactions, provides valuable insights into the factors that can affect drug absorption, metabolism, and efficacy. It underscores the importance of careful medication management and open communication between patients and their healthcare providers to minimize the risks of drug interactions.

A safer journey

The journey through the desert of medication is safer when we understand the potential hazards. This research reminds us that drug interactions are a significant factor in patient safety, emphasizing the importance of considering individual patient characteristics, medications, and potential interactions to optimize treatment outcomes. By understanding these complexities, we can create a safer and more predictable journey for patients who rely on medications to manage their health.

Dr. Camel's Conclusion

This research is like a caravan of scientists diligently exploring the vast desert of drug interactions, seeking to unravel its mysteries and provide safer and more effective treatment for patients. By understanding the intricate interplay of medications, we can navigate the desert of complexities and ensure a safer journey for all.

Date :
  1. Date Completed 2012-06-14
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

22348413

DOI: Digital Object Identifier

10.1111/j.1742-7843.2012.00858.x

SNS
PICO Info
in preparation
Languages

English

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