A single-dose placebo- and moxifloxacin-controlled study of the effects of temsirolimus on cardiac repolarization in healthy adults.

Author: BoniJoseph P, BurnsJaime, HugBruce, LeisterCathie, SonnichsenDaryl

Paper Details 
Original Abstract of the Article :
Temsirolimus, a selective inhibitor of mammalian target of rapamycin, is an approved treatment for patients with advanced renal cell carcinoma (RCC). This study assessed the effect of intravenous (i.v.) temsirolimus 25 mg, the recommended dose for patients with RCC, on the corrected QT (QTc) interva...See full text at original site
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引用元:
https://doi.org/10.1007/s00280-012-1845-7

データ提供:米国国立医学図書館(NLM)

Temsirolimus: A Cardiac Journey Through the Desert of Drug Development

Temsirolimus, a drug used to treat advanced renal cell carcinoma (RCC), is undergoing rigorous testing to ensure its safety and effectiveness. This research examines the potential impact of temsirolimus on cardiac repolarization, a crucial process in maintaining a healthy heartbeat. The study investigates the effects of intravenous temsirolimus on the corrected QT (QTc) interval, a measure of cardiac repolarization. This research aims to provide valuable information for clinicians prescribing temsirolimus, ensuring patient safety while optimizing treatment efficacy.

Monitoring Cardiac Repolarization: A Crucial Step in Temsirolimus Treatment

The research findings highlight the importance of monitoring cardiac repolarization in patients receiving temsirolimus. The study demonstrates that temsirolimus can potentially affect the QTc interval, a measure of cardiac repolarization. These findings underscore the need for careful monitoring of cardiac function in patients treated with temsirolimus, particularly those with pre-existing cardiac conditions. This research underscores the importance of a multidisciplinary approach to managing patients receiving temsirolimus, ensuring comprehensive monitoring and tailored treatment strategies.

A Beacon in the Desert: Navigating Temsirolimus Treatment Safely

This research provides valuable insights into the potential cardiac effects of temsirolimus, highlighting the importance of careful monitoring and individualized treatment strategies. By understanding the potential impact of temsirolimus on cardiac repolarization, clinicians can ensure the safe and effective use of this drug for patients with RCC. This research serves as a beacon in the desert of drug development, guiding clinicians towards safe and effective treatment strategies.

Dr.Camel's Conclusion

This research serves as a reminder of the importance of vigilant monitoring during drug development. By exploring the potential cardiac effects of temsirolimus, the study emphasizes the need for careful evaluation to ensure patient safety. It's a testament to the importance of responsible drug development, where each step forward requires careful consideration and evaluation. Like a cautious camel traversing a vast desert, researchers must proceed with a keen awareness of the potential challenges and ensure that every step is taken with safety and efficacy in mind.
Date :
  1. Date Completed 2012-08-03
  2. Date Revised 2018-12-11
Further Info :

Pubmed ID

22367193

DOI: Digital Object Identifier

10.1007/s00280-012-1845-7

Related Literature

SNS
PICO Info
in preparation
Languages

English

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