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Different effects of the selective serotonin reuptake inhibitors fluvoxamine, paroxetine, and sertraline on the pharmacokinetics of fexofenadine in healthy volunteers.

Author: AkamineYumiko, KanekoSunao, NiiokaTakenori, SaruwatariJunji, TakashimaAyaka, UnoTsukasa, Yasui-FurukoriNorio

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined the effects of commonly used selective serotonin reuptake inhibitors (SSRIs) on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate. It found that fluvoxamine and paroxetine significantly increased fexofenadine's exposure, likely due to P-glycoprotein inhibition in the small intestine or liver. Sertraline did not have a notable effect on fexofenadine's pharmacokinetics.
Paper Details　
Original Abstract of the Article :
Although the interaction between selective serotonin reuptake inhibitors (SSRIs) and other drugs is important in the treatment of depression, there have been few studies of SSRIs concerning transporter-mediated interactions in humans. The objective of this study was to evaluate the in vivo effects o...See full text at original site
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引用元：
https://doi.org/10.1097/JCP.0b013e318248ddb9

データ提供：米国国立医学図書館（NLM）

Impact of Selective Serotonin Reuptake Inhibitors on Fexofenadine Pharmacokinetics

This research dives deep into the complex interactions between commonly used medications, particularly selective serotonin reuptake inhibitors (SSRIs) and the antihistamine fexofenadine. The researchers investigated the impact of three SSRIs, fluvoxamine, paroxetine, and sertraline, on the pharmacokinetics of fexofenadine. They utilized a controlled study with healthy volunteers to determine the effects of these medications on the absorption, distribution, metabolism, and elimination of fexofenadine. Their findings revealed that [specific findings], highlighting the need for caution when prescribing these medications together.

Drug Interactions: Navigating the Desert of Medication Combinations

This study highlights the importance of understanding potential drug interactions, which is like navigating a desert with shifting sands. The researchers found that fluvoxamine and paroxetine, but not sertraline, significantly impacted the pharmacokinetic profile of fexofenadine. These findings suggest that clinicians need to be aware of these interactions to ensure safe and effective treatment for patients taking both SSRIs and fexofenadine.

Important Implications for Prescribing Practices

This research provides crucial insights for clinicians prescribing both SSRIs and fexofenadine. The findings indicate that drug interactions can significantly alter the efficacy and safety of medications. It emphasizes the importance of careful monitoring and individualized adjustments for patients taking these medications together.

Dr.Camel's Conclusion

This research reminds us that the world of medication interactions can be as vast and complex as a desert landscape. Clinicians need to be vigilant in understanding potential interactions and making informed decisions to ensure the safety and well-being of their patients.

Date :
  1. Date Completed 2012-06-18
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

22367658

DOI: Digital Object Identifier

10.1097/JCP.0b013e318248ddb9

Related Literature

Article Analysis
・Effects of fexofenadine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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