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Recent advances in the development of 14-alkoxy substituted morphinans as potent and safer opioid analgesics.

Author: SchmidhammerH, SpeteaM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

The study explores the development of novel opioid analgesics with reduced side effects compared to morphine. The research focused on 14-alkoxymorphinans, a class of potent μ opioid receptor (MOR) agonists. While initial compounds showed high analgesic potency but also morphine-like side effects, modifications led to compounds with reduced side effects. The research further explored the therapeutic potential of peripheral opioid receptors by designing compounds with limited access to the central nervous system (CNS), aiming to treat pain without central side effects.
Paper Details　
Original Abstract of the Article :
Morphine and other opioid morphinans produce analgesia primarily through μ opioid receptors (MORs), which mediate beneficial but also non-beneficial actions. There is a continued search for efficacious opioid analgesics with reduced complications. The cornerstone in the development of 14-alkoxymorph...See full text at original site
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引用元：
https://doi.org/10.2174/092986712800269308

データ提供：米国国立医学図書館（NLM）

Morphinans: A Quest for Safer Pain Relief

This study explores the development of 14-alkoxy substituted morphinans, a class of potent opioid analgesics. The research focuses on creating opioid drugs that provide effective pain relief while minimizing the risks of adverse effects. The authors discuss the strategies used to design these novel analgesics, highlighting the importance of targeting specific opioid receptors and reducing central nervous system penetration.

A New Generation of Morphinans: Striving for Balance

The study delves into the intricate world of opioid receptors and the challenges associated with developing analgesics that effectively target pain without triggering undesirable side effects. The research highlights the advancements in medicinal chemistry, demonstrating how modifications to the molecular structure of morphinans can lead to compounds with enhanced potency and reduced adverse effects. It's a testament to the tireless efforts of scientists to find safer and more effective pain management solutions.

Pain Relief: Navigating the Desert of Opioid Therapy

The findings of this study offer a promising path towards safer and more effective pain management. The research emphasizes the importance of understanding the complex interactions between opioids and the body, particularly the different types of opioid receptors. By targeting these receptors selectively and reducing central nervous system penetration, researchers are striving to create analgesics that provide effective pain relief while minimizing the risks of addiction and other adverse effects. It's like finding a safe and reliable route through the desert, avoiding the pitfalls and dangers along the way.

Dr.Camel's Conclusion

This study illuminates the ongoing quest for safer and more effective pain management strategies. The development of 14-alkoxy substituted morphinans showcases the potential of medicinal chemistry to create novel analgesics with enhanced potency and reduced adverse effects. As we delve deeper into the intricate mechanisms of pain perception and opioid action, we're closer to finding solutions that alleviate pain without compromising patient safety.

Date :
  1. Date Completed 2012-10-26
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

22455592

DOI: Digital Object Identifier

10.2174/092986712800269308

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・Side Effects of oxymorphone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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