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A randomized, 2-period, crossover design study to assess the effects of dexlansoprazole, lansoprazole, esomeprazole, and omeprazole on the steady-state pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers.

Author: BhattDeepak L, BrooksJulie K, FrelingerAndrew L, LeeRonald D, MichelsonAlan D, MulfordDarcy J, NigamAnu, NudurupatiSai, WuJingtao

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Generation of clopidogrel active metabolite and inhibition of platelet function were reduced less by the coadministration of dexlansoprazole or lansoprazole with clopidogrel than by the coadministration of esomeprazole or omeprazole. These results suggest that the potential of PPIs to attenuate the efficacy of clopidogrel could be minimized by the use of dexlansoprazole or lansoprazole rather than esomeprazole or omeprazole.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: The aim of this study was to assess the effects of different proton pump inhibitors (PPIs) on the steady-state pharmacokinetics and pharmacodynamics of clopidogrel. BACKGROUND: Metabolism of clopidogrel requires cytochrome P450s (CYPs), including CYP2C19. However, PPIs may inhibit CYP2C...See full text at original site
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引用元：
https://doi.org/10.1016/j.jacc.2011.12.024

データ提供：米国国立医学図書館（NLM）

Proton Pump Inhibitors and Clopidogrel: Potential Interactions

Clopidogrel is a widely prescribed antiplatelet medication used to prevent blood clots. Proton pump inhibitors (PPIs) are medications used to reduce stomach acid production. This randomized, crossover study investigates the potential interactions between clopidogrel and various PPIs. The study involved healthy volunteers and focused on the pharmacokinetics and pharmacodynamics of clopidogrel when co-administered with different PPIs.

The researchers found that certain PPIs, such as esomeprazole and omeprazole, significantly reduced the effectiveness of clopidogrel by inhibiting its metabolism. However, dexlansoprazole and lansoprazole had a smaller impact on clopidogrel's efficacy.

PPI Use: Potential Implications for Clopidogrel Therapy

These findings suggest that the choice of PPI can significantly impact the effectiveness of clopidogrel therapy. Clinicians should carefully consider the potential interactions between PPIs and clopidogrel when prescribing these medications.

Medication Safety: Importance of Patient-Provider Communication

This study emphasizes the importance of open communication between patients and healthcare providers regarding their medications. Patients should inform their doctors about all medications they are taking, including over-the-counter drugs, to ensure safe and effective treatment.

Dr. Camel's Conclusion

Imagine a desert oasis where a caravan is traveling with valuable cargo. Clopidogrel represents the precious cargo, protecting against the dangers of blood clots. PPIs, in this analogy, are like different types of desert winds. Some winds can disrupt the caravan's journey (esomeprazole and omeprazole), while others have a less significant impact (dexlansoprazole and lansoprazole). Understanding these interactions helps us navigate the desert safely and protect the valuable cargo.

Date :
  1. Date Completed 2012-05-17
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

22464259

DOI: Digital Object Identifier

10.1016/j.jacc.2011.12.024

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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