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Methodology and lessons-learned from the efficacy clinical trial of the pentavalent rotavirus vaccine in Bangladesh.

Author: AzimTasnim, CiarletMax, DallasMichael J, El ArifeenShams, FaruqueA S G, HossainIlias, HuqEhsanul, LewisKristen D C, LubyStephen P, NeuzilKathleen M, RiversStephen B, SackDavid A, SteeleA Duncan, VictorJohn C, YunusM, ZamanK

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This clinical trial in rural Bangladesh evaluated the efficacy and safety of a pentavalent rotavirus vaccine (PRV), RotaTeq(®), in infants. The vaccine was well accepted in the community and successfully completed. A total of 1128 infants received 3 doses of PRV/placebo and efficacy follow-up was conducted for a median of 554 days. The efficacy of PRV against severe rotavirus gastroenteritis was 42.7% and serum anti-rotavirus IgA response was 78.1%. There were 39 serious adverse events, including 6 deaths, among study participants.
Paper Details　
Original Abstract of the Article :
An efficacy clinical trial with pentavalent rotavirus vaccine (PRV), RotaTeq(®), was conducted at Matlab field site of ICDDR,B, Bangladesh from March 2007 to March 2009. The methodology, including operation logistics, and lessons-learned are described in this report. Vaccination was organized at 41 ...See full text at original site
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引用元：
https://doi.org/10.1016/j.vaccine.2011.07.117

データ提供：米国国立医学図書館（NLM）

Methodology and Lessons Learned from the Efficacy Clinical Trial of the Pentavalent Rotavirus Vaccine in Bangladesh

This study delves into the world of vaccine research, focusing on the efficacy clinical trial of the pentavalent rotavirus vaccine (PRV), RotaTeq(®), conducted in Bangladesh. The authors provide a comprehensive description of the methodology employed, including operation logistics, and highlight key lessons learned from the trial. The study's findings offer valuable insights into the implementation of vaccine trials in resource-limited settings, contributing to the development of effective public health interventions.

Lessons Learned from a Rotavirus Vaccine Trial in Bangladesh

This study provides valuable insights into the implementation of vaccine trials in resource-limited settings, using the example of a pentavalent rotavirus vaccine (PRV) trial conducted in Bangladesh. The authors highlight the challenges and successes encountered, including operational logistics and lessons learned. The study's findings offer practical guidance for future vaccine trials in similar settings, contributing to the development and implementation of effective public health interventions.

Vaccines in Action: Lessons from a Rotavirus Vaccine Trial in Bangladesh

This study highlights the importance of vaccine trials in resource-limited settings, using the example of a pentavalent rotavirus vaccine (PRV) trial conducted in Bangladesh. The authors provide a detailed account of the methodology employed, including operation logistics, and share key lessons learned. The study's findings offer valuable insights into the challenges and successes encountered during the trial, informing future vaccine trials in similar settings and contributing to the development of effective public health interventions. Just as a camel navigates the harsh desert environment with resilience and adaptability, researchers and healthcare providers work tirelessly to overcome challenges and implement effective public health interventions, ensuring the well-being of communities around the world.

Dr. Camel's Conclusion

This study is a reminder that the journey toward better health often takes us to unexpected places, just as a camel traverses the vastness of the desert. This research, conducted in Bangladesh, provides valuable lessons learned from a rotavirus vaccine trial, highlighting the challenges and successes encountered in implementing public health interventions. These insights are essential for ensuring the effectiveness and reach of vaccines in resource-limited settings, paving the way for a healthier future for all.

Date :
  1. Date Completed 2012-08-08
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

22520143

DOI: Digital Object Identifier

10.1016/j.vaccine.2011.07.117

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Languages

English

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