Paper Details

  1. Home
  2. Paper Details

Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors.

Author: BlikslagerAnthony T, ChakrabartiJayati, CuppolettiJohn, MalinowskaDanuta H, NighotPrashant K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined the effects of linaclotide on the repair of barrier and cell function after ischemia in pig jejunum and after treatment with proinflammatory cytokines in T84 cells.
Paper Details　
Original Abstract of the Article :
Linaclotide has been proposed as a treatment for the same gastrointestinal indications for which lubiprostone has been approved, chronic idiopathic constipation and irritable bowel syndrome with constipation. Stressors damage the epithelial cell barrier and cellular homeostasis leading to loss of th...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403872/

データ提供：米国国立医学図書館（NLM）

Linaclotide and Lubiprostone: Two Different Paths in the Desert of Gastrointestinal Distress

This study explores the vast desert of gastrointestinal disorders, comparing the effects of two medications, linaclotide and lubiprostone, on the healing process of the gut lining. These medications are used to treat constipation and irritable bowel syndrome with constipation, conditions that often leave people feeling stranded in a desert of discomfort.

Linaclotide and Lubiprostone: Each With Its Own Oasis of Benefits

The study found that both linaclotide and lubiprostone promote the repair of the epithelial cell barrier and contribute to cellular homeostasis, essentially offering a unique oasis of healing within the digestive system. However, the study also highlighted that these medications may have different mechanisms of action, suggesting that one might be more effective than the other depending on the specific condition and individual patient.

Navigating the Desert of Gastrointestinal Issues: Finding the Right Oasis

This research underscores the importance of carefully considering the specific needs of each patient when choosing a treatment for gastrointestinal disorders. There may be multiple oases of relief available, and finding the right one for each individual can be crucial. The study also emphasizes the need for further research to understand the full potential of both linaclotide and lubiprostone in managing these conditions.

Dr. Camel's Conclusion

This study showcases the complexities of navigating the desert of gastrointestinal disorders. Linaclotide and lubiprostone offer potential oases of relief, but finding the right treatment for each individual requires careful consideration and a personalized approach. Continued research will undoubtedly reveal more about the nuances of these medications and help us better understand the best paths to healing.
Date :
  1. Date Completed 2012-12-04
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22553939

DOI: Digital Object Identifier

PMC3403872

Related Literature

Article Analysis
・Effects of linaclotide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.