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A dicarboxylic fatty acid derivative of paclitaxel for albumin-assisted drug delivery.

Author: ChoMoo J, GuleyPatrick C, HackettMichael J, HartranftMegan E, JoolakantiShyamsunder

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study presents a method for solubilizing paclitaxel (PTX) by conjugating it with a dicarboxylic fatty acid for specific binding to serum albumin. The resulting PDG derivative was less cytotoxic, slowly hydrolyzed to PTX, and exhibited improved pharmacokinetic properties compared to the TAXOL formulation.
Paper Details　
Original Abstract of the Article :
Paclitaxel (PTX) is a potent chemotherapy for many cancers but it suffers from very poor solubility. Consequently, the TAXOL formulation uses copious amounts of the surfactant Cremophor EL to solubilize the drug for injection, resulting in severe hypersensitivity and neutropenia. In contrast to Crem...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/22674061

データ提供：米国国立医学図書館（NLM）

A Novel Approach to Paclitaxel Delivery: A Dicarboxylic Fatty Acid Revolution

Paclitaxel, a potent chemotherapy drug used to treat various cancers, faces a major hurdle: its poor solubility. This limitation has led to the use of Cremophor EL, a surfactant that can cause serious side effects. This research proposes a novel approach to paclitaxel delivery, employing a dicarboxylic fatty acid derivative for enhanced solubility and reduced toxicity.

Harnessing the Power of Albumin: A New Delivery System

The researchers developed a method for solubilizing paclitaxel by conjugating it with a dicarboxylic fatty acid. This derivative specifically binds to albumin, a ubiquitous protein found in the bloodstream. The resulting compound exhibits reduced cytotoxicity and slowly hydrolyzes to release paclitaxel within the body, potentially improving its delivery to tumor cells.

A New Oasis in Chemotherapy Delivery

This research, like a camel finding a hidden oasis in the vast desert, presents a promising alternative to traditional paclitaxel delivery methods. By leveraging the power of albumin, the researchers have created a potentially safer and more effective way to deliver this potent chemotherapy drug. This innovative approach could significantly improve the lives of cancer patients by reducing side effects and enhancing treatment efficacy.

Dr.Camel's Conclusion

This research presents an innovative approach to paclitaxel delivery, utilizing a dicarboxylic fatty acid derivative for enhanced solubility and reduced toxicity. By harnessing the power of albumin, the researchers have devised a potential solution to the challenges associated with traditional paclitaxel delivery methods. This research, like a camel navigating the vast and unforgiving desert of cancer treatment, offers hope for a future where chemotherapy can be administered with greater safety and effectiveness.
Date :
  1. Date Completed 2012-12-07
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22674061

DOI: Digital Object Identifier

NIHMS450237

Related Literature

Article Analysis
・Effects of paclitaxel (with albumin) injection
SNS
PICO Info
in preparation
Languages

English

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